Liquid‐assisted grinding mechanochemistry in the synthesis of pharmaceuticals

P Ying, J Yu, W Su - Advanced Synthesis & Catalysis, 2021 - Wiley Online Library
Mechanochemical reactions by milling, grinding or other types of mechanical action have
emerged as a salient green approach because of its wide applications towards academic …

Praziquantel–50 years of research

A Waechtler, B Cezanne, D Maillard, R Sun… - …, 2023 - Wiley Online Library
Investigations on praziquantel (PZQ) started fifty years ago by a cooperation between Bayer
AG and Merck KGaA. Until today PZQ is the drug of choice for schistosomiasis in human …

The anthelmintic drug praziquantel activates a schistosome transient receptor potential channel

SK Park, GS Gunaratne, EG Chulkov… - Journal of Biological …, 2019 - ASBMB
The anthelmintic drug praziquantel (PZQ) is used to treat schistosomiasis, a neglected
tropical disease that affects over 200 million people worldwide. PZQ causes Ca 2+ influx …

Searching for Conglomerate Cocrystals of the Racemic Compound Praziquantel

P Rapeenun, CJJ Gerard, C Pinètre… - Crystal Growth & …, 2023 - ACS Publications
Chiral compounds that crystallize as conglomerates from racemic mixtures are desirable
from the perspective of chiral resolution since they are relatively easy to resolve using, for …

Praziquantel: An update on the mechanism of its action against schistosomiasis and new therapeutic perspectives

RA Nogueira, MGS Lira, ICL Licá, GCCG Frazão… - Molecular and …, 2022 - Elsevier
Praziquantel (PZQ) is the drug of choice for the treatment of all forms of schistosomiasis,
although its mechanisms of action are not completely understood. PZQ acts largely on adult …

[PDF][PDF] Albendazole and praziquantel: review and safety monitoring in Korea

ST Hong - Infection & chemotherapy, 2018 - synapse.koreamed.org
Albendazole (ADZ) and praziquantel (PZQT) have been used as anthelmintics for over 30
years. Worldwide, hundreds of millions tablets are administered to people and livestock …

A review of the genetic determinants of praziquantel resistance in Schistosoma mansoni: Is praziquantel and intestinal schistosomiasis a perfect match?

S Summers, T Bhattacharyya, F Allan… - Frontiers in Tropical …, 2022 - frontiersin.org
Schistosomiasis is a neglected tropical disease (NTD) caused by parasitic trematodes
belonging to the Schistosoma genus. The mainstay of schistosomiasis control is the delivery …

Efficacy, safety, and palatability of arpraziquantel (L-praziquantel) orodispersible tablets in children aged 3 months to 6 years infected with Schistosoma in Côte d' …

EK N'Goran, MR Odiere, RA Aka… - The Lancet Infectious …, 2023 - thelancet.com
Background WHO has underlined the need for a child-friendly treatment for schistosomiasis,
a prevalent parasitic disease in low-income and middle-income countries. After successful …

Progress interrogating TRPMPZQ as the target of praziquantel

JS Marchant - PLOS Neglected Tropical Diseases, 2024 - journals.plos.org
The drug praziquantel (PZQ) has served as the long-standing drug therapy for treatment of
infections caused by parasitic flatworms. These encompass diseases caused by parasitic …

Effect of pharmacogenetic variations on praziquantel plasma concentration and safety outcomes among school children in Rwanda

A Barry, J Kabatende, NF Telele, RH Mnkugwe… - Scientific Reports, 2023 - nature.com
School-based mass drug administration (MDA) of Praziquantel (PZQ) is the global
intervention strategy for elimination of schistosomiasis. Genetic variations in drug …