Nucleolin or C23, is one of the most abundant non-ribosomal phosphoproteins of nucleolus.
However, in several cancers, nucleolin is highly expressed both intracellularly and on the …

There is a surge in demand for safe and targeted therapy against cancer as the conventional
treatment approach fails to reach the specific site. Chemotherapeutic agents are generally …

Aptamers are single-stranded DNA or RNA with 20-100 nucleotides in length that can
specifically bind to target molecules via formed three-dimensional structures. These …

In regard to tremendous toxicological effects of aflatoxin B1 (AFB1) and its major metabolite
aflatoxin M1 (AFM1) on human health, quality assessment of food is of great importance. On …

In the current study camptothecin-loaded pegylated PAMAM dendrimer were synthesized
and were functionalized with AS1411 anti-nucleolin aptamers for site-specific targeting …

Most problems associated with chemotherapeutic agents involve non-specific cytotoxicity,
low intratumoral accumulation and drug resistance. Targeted drug delivery systems (TDDS) …

In recent years, many stimuli-triggered drug delivery platforms have been designed to
deliver drugs accurately to specific sites and reduce their side effects, improving “on …

Herein, a nanotherapeutic delivery method was presented for co-delivery of doxorubicin
(DOX) and aptamer against Forkhead box M1 (FOXM1 Apt) to cancer cells. Firstly, the …

Aptamers are short and single-stranded DNA or RNA molecules with highly programmable
structures that give them the ability to interact specifically with a large variety of targets …

Aptamers are single-stranded DNA or RNA oligomers that have the ability to generate
unique and diverse tertiary structures that bind to cognate molecules with high specificity. In …