Toward merging untargeted and targeted methods in mass spectrometry-based metabolomics and lipidomics

T Cajka, O Fiehn - Analytical chemistry, 2016 - ACS Publications
Advances in mass spectrometry (MS) and data processing have led to discoveries in
regulation of cellular metabolism by using metabolomics and lipidomics approaches. 1, 2 …

Metabolomics toward personalized medicine

M Jacob, AL Lopata, M Dasouki… - Mass spectrometry …, 2019 - Wiley Online Library
Metabolomics, which is the metabolites profiling in biological matrices, is a key tool for
biomarker discovery and personalized medicine and has great potential to elucidate the …

On-line vis-NIR spectroscopy prediction of soil organic carbon using machine learning

S Nawar, AM Mouazen - Soil and Tillage Research, 2019 - Elsevier
Accurate on-line visible and near infrared (vis-NIR) spectroscopy prediction of soil organic
carbon (OC) is essential for food security and environmental management. This paper aims …

Comparison between random forests, artificial neural networks and gradient boosted machines methods of on-line Vis-NIR spectroscopy measurements of soil total …

S Nawar, AM Mouazen - Sensors, 2017 - mdpi.com
Accurate and detailed spatial soil information about within-field variability is essential for
variable-rate applications of farm resources. Soil total nitrogen (TN) and total carbon (TC) …

A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation

C Yanchus, KL Drucker, TM Kollmeyer, R Tsai… - Science, 2022 - science.org
Establishing causal links between inherited polymorphisms and cancer risk is challenging.
Here, we focus on the single-nucleotide polymorphism rs55705857, which confers a sixfold …

The GATOR–Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids

GG Hesketh, F Papazotos, J Pawling, D Rajendran… - Science, 2020 - science.org
The mechanistic target of rapamycin complex 1 (mTORC1) couples nutrient sufficiency to
cell growth. mTORC1 is activated by exogenously acquired amino acids sensed through the …

Rapid prediction of total petroleum hydrocarbons concentration in contaminated soil using vis-NIR spectroscopy and regression techniques

RK Douglas, S Nawar, MC Alamar, AM Mouazen… - Science of the Total …, 2018 - Elsevier
Visible and near infrared spectrometry (vis-NIRS) coupled with data mining techniques can
offer fast and cost-effective quantitative measurement of total petroleum hydrocarbons (TPH) …

Inborn errors of metabolism in the era of untargeted metabolomics and lipidomics

IT Ismail, MR Showalter, O Fiehn - Metabolites, 2019 - mdpi.com
Inborn errors of metabolism (IEMs) are a group of inherited diseases with variable
incidences. IEMs are caused by disrupting enzyme activities in specific metabolic pathways …

PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia

RS Banh, C Iorio, R Marcotte, Y Xu, D Cojocari… - Nature cell …, 2016 - nature.com
Tumours exist in a hypoxic microenvironment and must limit excessive oxygen consumption.
Hypoxia-inducible factor (HIF) controls mitochondrial oxygen consumption, but how/if …

Simultaneous metabolite, protein, lipid extraction (SIMPLEX): a combinatorial multimolecular omics approach for systems biology

C Coman, FA Solari, A Hentschel, A Sickmann… - Molecular & cellular …, 2016 - ASBMB
Interconnected molecular networks are at the heart of signaling pathways that mediate
adaptive plasticity of eukaryotic cells. To gain deeper insights into the underlying molecular …