Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …

The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

Major features of the transcellular signaling mechanism responsible for endothelium-
dependent regulation of vascular smooth muscle tone are unresolved. We identified local …

Systemic blood pressure is acutely controlled by total peripheral resistance as determined
by the diameter of small arteries and arterioles, the contractility of which is regulated by …

Inflammation is a complex and potentially life-threatening condition that involves the
participation of a variety of chemical mediators, signaling pathways, and cell types. The …

The term endothelium-derived hyperpolarising factor (EDHF) was introduced in 1987 to
describe the hypothetical factor responsible for myocyte hyperpolarisations not associated …

The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also
by other pathways causing hyperpolarization of the underlying smooth muscle cells. This …

The transient receptor potential (TRP) superfamily consists of a large number of
nonselective cation channels with variable degree of Ca2+-permeability. The 28 mammalian …

The transient receptor potential vallinoid type 4 (TRPV4) channel has been implicated in the
endothelial shear response and flow-mediated dilation, although the precise functions of this …

Background: Impaired endothelium-dependent vasodilation is a hallmark of obesity-induced
hypertension. The recognition that Ca2+ signaling in endothelial cells promotes vasodilation …