Schistosomiasis pulmonary arterial hypertension

JP Sibomana, A Campeche, RJ Carvalho-Filho… - Frontiers in …, 2020 - frontiersin.org
Pulmonary arterial hypertension (PAH) is a disease of the lung blood vessels that results in
right heart failure. PAH is thought to occur in about 5% to 10% of patients with hepatosplenic …

Cytokines, chemokines, and inflammation in pulmonary arterial hypertension

S Liang, AA Desai, SM Black, H Tang - … in Health and Disease, Volume I, 2021 - Springer
Abstract According to the World Symposium Pulmonary Hypertension (WSPH) classification,
pulmonary hypertension (PH) is classified into five categories based on etiology. Among …

Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice

G Chen, S Zuo, J Tang, C Zuo, D Jia, Q Liu… - Journal of Experimental …, 2018 - rupress.org
Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by
progressive pulmonary artery (PA) remodeling. T helper 2 cell (Th2) immune response is …

Th2 CD4+ T Cells Are Necessary and Sufficient for Schistosoma‐Pulmonary Hypertension

R Kumar, C Mickael, B Kassa, L Sanders… - Journal of the …, 2019 - Am Heart Assoc
Background Inflammation underlies many forms of pulmonary hypertension (PH), including
that resulting from Schistosoma infection, a major cause of PH worldwide. Schistosomiasis …

Prostaglandin D2 signaling and cardiovascular homeostasis

D Kong, Y Yu - Journal of Molecular and Cellular Cardiology, 2022 - Elsevier
Cardiovascular diseases are the leading cause of death worldwide. A chronic inflammatory
response is a common pathological alteration in diverse cardiovascular diseases …

Schistosome-associated pulmonary arterial hypertension: a review emphasizing pathogenesis

TCA Ferrari, ACL Albricker, IM Gonçalves… - Frontiers in …, 2021 - frontiersin.org
Schistosomiasis, especially due to Schistosoma mansoni, is a well-recognized cause of
pulmonary arterial hypertension (PAH). The high prevalence of this helminthiasis makes …

Update on the treatment of pulmonary arterial hypertension

CJ Fernandes, D Calderaro, APL Assad… - Arquivos brasileiros de …, 2021 - SciELO Brasil
In the last decades, important advances have been made in the treatment of pulmonary
arterial hypertension (PAH), a severe, progressive, incurable, and potentially fatal disease …

The Role of Type 2 Inflammation in Schistosoma-Induced Pulmonary Hypertension

CS Mickael, BB Graham - Frontiers in immunology, 2019 - frontiersin.org
Approximately 5% of individuals chronically infected with Schistosoma mansoni develop
pulmonary hypertension (PH). The disease is progressive and often fatal, and treatment …

Pulmonary hypertension: definition, classification, and diagnosis

JL Alves-Jr, FG Oleas, R Souza - Seminars in Respiratory and …, 2017 - thieme-connect.com
Pulmonary hypertension (PH) is a hemodynamic condition characterized by the presence of
mean pulmonary artery pressure≥ 25 mm Hg. Many different baseline conditions and/or risk …

Pulmonary hypertension in majority countries: opportunities amidst challenges

GJ Maarman, J Shaw, B Allwood - Current Opinion in Pulmonary …, 2020 - journals.lww.com
There is urgent need for pulmonary hypertension advocacy among clinicians in the primary,
secondary and tertiary healthcare sectors of majority countries, and validated noninvasive …