The intestinal barrier is essential in human health and constitutes the interface between the
outside and the internal milieu of the body. A functional intestinal barrier allows absorption of …

Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes.
The exact mechanism by which adipose tissue induces insulin resistance is still unclear. It …

Sepsis is a life-threatening condition and a global disease burden. Today, the
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …

Inflammation plays an essential role in the control of pathogens and in shaping the ensuing
adaptive immune responses. Traditionally, innate immunity has been described as a rapid …

Adipose tissue is an immunologically active organ that controls host physiology, partly
through the release of mediators termed adipokines. In obesity, adipocytes and infiltrating …

The scientific interest in the beneficial properties of natural substances has been recognized
for decades, as well as the growing attention in extracellular vesicles (EVs) released by …

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is an autoimmune
disorder which affects small-and, to a lesser degree, medium-sized vessels. ANCA …

Iron is indispensable for almost all forms of life but toxic at elevated levels,,–. To survive
within their hosts, bacterial pathogens have evolved iron uptake, storage and detoxification …

Background and Aims Vitamin D exerts a regulatory role over mucosal immunity via the
vitamin D receptor (VDR). Although Paneth cells and their products are known to regulate …

Lipocalin-2 (LCN2) is a secreted glycoprotein linked to several physiological roles, including
transporting hydrophobic ligands across cell membranes, modulating immune responses …