The role of sex and sex hormones in neurodegenerative diseases
E Vegeto, A Villa, S Della Torre, V Crippa… - Endocrine …, 2020 - academic.oup.com
Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …
Androgen receptor in prostate cancer
CA Heinlein, C Chang - Endocrine reviews, 2004 - academic.oup.com
The normal development and maintenance of the prostate is dependent on androgen acting
through the androgen receptor (AR). AR remains important in the development and …
through the androgen receptor (AR). AR remains important in the development and …
Androgen receptor activity in T cells limits checkpoint blockade efficacy
Immune checkpoint blockade has revolutionized the field of oncology, inducing durable anti-
tumour immunity in solid tumours. In patients with advanced prostate cancer …
tumour immunity in solid tumours. In patients with advanced prostate cancer …
[HTML][HTML] Elimination of toxic microsatellite repeat expansion RNA by RNA-targeting Cas9
Microsatellite repeat expansions in DNA produce pathogenic RNA species that cause
dominantly inherited diseases such as myotonic dystrophy type 1 and 2 (DM1/2) …
dominantly inherited diseases such as myotonic dystrophy type 1 and 2 (DM1/2) …
Tandem repeats finder: a program to analyze DNA sequences
G Benson - Nucleic acids research, 1999 - academic.oup.com
A tandem repeat in DNA is two or more contiguous, approximate copies of a pattern of
nucleotides. Tandem repeats have been shown to cause human disease, may play a variety …
nucleotides. Tandem repeats have been shown to cause human disease, may play a variety …
Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member
JD Brook, ME McCurrach, HG Harley, AJ Buckler… - Cell, 1992 - cell.com
Using positional cloning strategies, we have identified a CTG triplet repeat that undergoes
expansion in myotonic dystrophy patients. This sequence is highly variable in the normal …
expansion in myotonic dystrophy patients. This sequence is highly variable in the normal …
High resolution of human evolutionary trees with polymorphic microsatellites
AM Bowcock, A Ruiz-Linares, J Tomfohrde, E Minch… - Nature, 1994 - nature.com
GENETIC variation at hypervariable loci is being used extensively for linkage analysis1 and
individual identification2, and may be useful for inter-population studies2–5. Here we show …
individual identification2, and may be useful for inter-population studies2–5. Here we show …
Microsatellite analysis of population structure in Canadian polar bears
D Paetkau, W Calvert, I Stirling, C Strobeck - Molecular ecology, 1995 - Wiley Online Library
Attempts to study the genetic population structure of large mammals are often hampered by
the low levels of genetic variation observed in these species. Polar bears have particularly …
the low levels of genetic variation observed in these species. Polar bears have particularly …
The evolutionary dynamics of repetitive DNA in eukaryotes
B Charlesworth, P Sniegowski, W Stephan - Nature, 1994 - nature.com
Repetitive DNA sequences form a large portion of the genomes of eukaryotes. The'selfish
DNA'hypothesis proposes that they are maintained by their ability to replicate within the …
DNA'hypothesis proposes that they are maintained by their ability to replicate within the …
Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation.
The human androgen-receptor gene (HUMARA; GenBank) contains a highly polymorphic
trinucleotide repeat in the first exon. We have found that the methylation of HpaII and HhaI …
trinucleotide repeat in the first exon. We have found that the methylation of HpaII and HhaI …