European guideline on indications, performance, and clinical impact of hydrogen and methane breath tests in adult and pediatric patients: European Association for …

HF Hammer, MR Fox, J Keller… - United European …, 2022 - Wiley Online Library
Introduction Measurement of breath hydrogen (H2) and methane (CH4) excretion after
ingestion of test‐carbohydrates is used for different diagnostic purposes. There is a lack of …

IBS and IBD—separate entities or on a spectrum?

R Spiller, G Major - Nature reviews Gastroenterology & hepatology, 2016 - nature.com
The acute phase of IBD with inflamed gut and often ulcerated mucosa is clearly different
from the apparently normal mucosa characteristic of IBS. However, more detailed …

Colon hypersensitivity to distension, rather than excessive gas production, produces carbohydrate-related symptoms in individuals with irritable bowel syndrome

G Major, S Pritchard, K Murray, JP Alappadan… - Gastroenterology, 2017 - Elsevier
Background & Aims Poorly digested, fermentable carbohydrates may induce symptoms of
irritable bowel syndrome (IBS) via unclear mechanisms. We performed a randomized trial …

[HTML][HTML] Low FODMAP diet reduces gastrointestinal symptoms in irritable bowel syndrome and clinical response could be predicted by symptom severity: A …

JP Algera, D Demir, H Törnblom, S Nybacka, M Simrén… - Clinical Nutrition, 2022 - Elsevier
Background & aims Fermentable oligo-, di-, monosaccharides and polyols (FODMAPs) can
provoke symptoms in patients with irritable bowel syndrome (IBS). We aimed to compare the …

New treatments and therapeutic targets for IBS and other functional bowel disorders

M Simrén, J Tack - Nature Reviews Gastroenterology & Hepatology, 2018 - nature.com
Functional bowel disorders (FBDs) are a spectrum of disorders characterized by
combinations of symptoms attributable to the lower gastrointestinal tract. Most current first …

Evidence for an association of gut microbial Clostridia with brain functional connectivity and gastrointestinal sensorimotor function in patients with irritable bowel …

JS Labus, V Osadchiy, EY Hsiao, J Tap, M Derrien… - Microbiome, 2019 - Springer
Background and aims Evidence from preclinical and clinical studies suggests that
interactions among the brain, gut, and microbiota may affect the pathophysiology of irritable …

Fermentable oligosaccharides, disaccharides, monosaccharides and polyols: role in irritable bowel syndrome

CJ Tuck, JG Muir, JS Barrett… - Expert review of …, 2014 - Taylor & Francis
Irritable bowel syndrome (IBS) was previously left poorly treated despite its high prevalence
and cost. Over the past decade, significant research has been conducted providing new …

Anxiety and depression in irritable bowel syndrome: Exploring the interaction with other symptoms and pathophysiology using multivariate analyses

I Midenfjord, A Polster, H Sjövall… - …, 2019 - Wiley Online Library
Background Anxiety or depression, in other words, psychological distress, are common
comorbidities in patients with irritable bowel syndrome (IBS), but their interaction with …

Microbiota: a novel regulator of pain

M Defaye, S Gervason, C Altier, JY Berthon… - Journal of neural …, 2020 - Springer
Among the various regulators of the nervous system, the gut microbiota has been recently
described to have the potential to modulate neuronal cells activation. While bacteria-derived …

Lactose intolerance in irritable bowel syndrome patients with diarrhoea: the roles of anxiety, activation of the innate mucosal immune system and visceral sensitivity

J Yang, M Fox, Y Cong, H Chu, X Zheng… - Alimentary …, 2014 - Wiley Online Library
Background Irritable bowel syndrome patients with diarrhoea (IBS‐D) often report
intolerance to milk; however, the mechanism underlying these symptoms is unknown. Aim …