mRNA Cancer vaccines: construction and boosting strategies
In late 2020, the US Food and Drug Administration (FDA) approved a lipid-based mRNA
vaccine for the prevention of COVID-19, which has pushed this field to be more closely …
vaccine for the prevention of COVID-19, which has pushed this field to be more closely …
Recent advances in nanoparticulate RNA delivery systems
Nanoparticle-based RNA delivery has shown great progress in recent years with the
approval of two mRNA vaccines for Severe Acute Respiratory Syndrome Coronavirus 2 …
approval of two mRNA vaccines for Severe Acute Respiratory Syndrome Coronavirus 2 …
Combinatorial development of nebulized mRNA delivery formulations for the lungs
Inhaled delivery of mRNA has the potential to treat a wide variety of diseases. However,
nebulized mRNA lipid nanoparticles (LNPs) face several unique challenges including …
nebulized mRNA lipid nanoparticles (LNPs) face several unique challenges including …
Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation
K Su, L Shi, T Sheng, X Yan, L Lin, C Meng… - Nature …, 2024 - nature.com
Fully targeted mRNA therapeutics necessitate simultaneous organ-specific accumulation
and effective translation. Despite some progress, delivery systems are still unable to fully …
and effective translation. Despite some progress, delivery systems are still unable to fully …
The 60-year evolution of lipid nanoparticles for nucleic acid delivery
PR Cullis, PL Felgner - Nature Reviews Drug Discovery, 2024 - nature.com
Delivery of genetic information to the interior of target cells in vivo has been a major
challenge facing gene therapies. This barrier is now being overcome, owing in part to …
challenge facing gene therapies. This barrier is now being overcome, owing in part to …
Dynamic carriers for therapeutic RNA delivery
Carriers for RNA delivery must be dynamic, first stabilizing and protecting therapeutic RNA
during delivery to the target tissue and across cellular membrane barriers and then …
during delivery to the target tissue and across cellular membrane barriers and then …
[HTML][HTML] Evolution of the structure of lipid nanoparticles for nucleic acid delivery: From in situ studies of formulation to colloidal stability
The development of lipid nanoparticle (LNP) based therapeutics for delivery of RNA has
triggered the advance of new strategies for formulation, such as high throughput …
triggered the advance of new strategies for formulation, such as high throughput …
Considerations on the design of lipid-based mRNA vaccines against cancer
Throughout the last decades, mRNA vaccines have been developed as a cancer
immunotherapeutic and the technology recently gained momentum during the COVID-19 …
immunotherapeutic and the technology recently gained momentum during the COVID-19 …
Phase‐Separated Lipid‐Based Nanoparticles: Selective Behavior at the Nano‐Bio Interface
P Papadopoulou, R van der Pol… - Advanced …, 2024 - Wiley Online Library
The membrane‐protein interface on lipid‐based nanoparticles influences their in vivo
behavior. Better understanding may evolve current drug delivery methods toward effective …
behavior. Better understanding may evolve current drug delivery methods toward effective …
Morphological characterization of self-amplifying mRNA lipid nanoparticles
The mRNA technology has emerged as a rapid modality to develop vaccines during
pandemic situations with the potential to protect against endemic diseases. The success of …
pandemic situations with the potential to protect against endemic diseases. The success of …