Amyotrophic lateral sclerosis is a fatal CNS neurodegenerative disease. Despite intensive
research, current management of amyotrophic lateral sclerosis remains suboptimal from …

Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …

The diagnosis of amyotrophic lateral sclerosis can be challenging due to its heterogeneity in
clinical presentation and overlap with other neurological disorders. Diagnosis early in the …

Amyotrophic lateral sclerosis (ALS) therapeutic development has largely relied on staff-
administered functional rating scales to determine treatment efficacy. We sought to …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
loss of upper and lower motor neurons, resulting in progressive weakness of all voluntary …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that
severely impacts affected persons' speech and motor functions, yet early detection and …

Strong evidence suggests that endoplasmic reticulum stress plays a critical role in the
pathogenesis of amyotrophic lateral sclerosis (ALS) through altered regulation of …

Abstract Objective: The ALSFRS-R is limited by multidimensionality, which originates from
the summation of various subscales. This prevents a direct comparison between patients …

Abstract Amyotrophic Lateral Sclerosis (ALS) disease severity is usually measured using the
subjective, questionnaire-based revised ALS Functional Rating Scale (ALSFRS-R) …

Background Selection of appropriate trial endpoints and outcome measures is particularly
important in rare disease and rapidly progressing disease such as amyotrophic lateral …