Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

Being the largest internal organ of the human body with the unique ability of self-
regeneration, the liver is involved in a wide variety of vital functions that require highly …

MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

Non-alcoholic fatty liver disease (NAFLD) is associated with a thorough reprogramming of
hepatic metabolism. Epigenetic mechanisms, in particular those associated with …

The discovery that gene expression can be controlled by the Watson–Crick base-pairing of
small RNAs with messenger RNAs containing complementary sequence—a process known …

Growing evidence indicates that microRNAs have a significant role in tumor development
and may constitute robust biomarkers for cancer diagnosis and prognosis. In this study, we …

Hepatitis C virus (HCV) is a positive strand RNA virus that propagates primarily in the liver.
We show here that the liver‐specific microRNA‐122 (miR‐122), a member of a class of small …

MicroRNAs are negative regulators of protein coding genes. The liver-specific microRNA-
122 (miR-122) is frequently suppressed in primary hepatocellular carcinomas (HCCs). In …

Nonalcoholic steatohepatitis (NASH) is considered as a progressive form of nonalcoholic
fatty liver disease (NAFLD). To distinguish NASH from nonalcoholic fatty liver (NAFL), we …

Interferons (IFNs) are key mediators of the host innate antiviral immune response. To identify
IFN-stimulated genes (ISGs) that instigate an antiviral state against two medically important …