The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

Tractable and accurate disease models are essential for understanding disease
pathogenesis and for developing new therapeutics. As stem cells are capable of self …

Abstract β-Thalassemia is one of the most common genetic blood diseases and is caused by
either point mutations or deletions in the β-globin (HBB) gene. The generation of patient …

The generation of beta-thalassemia (β-Thal) patient-specific induced pluripotent stem cells
(iPSCs), subsequent homologous recombination-based gene correction of disease-causing …

Duchenne muscular dystrophy is a progressive and incurable neuromuscular disease
caused by genetic and biochemical defects of the dystrophin–glycoprotein complex. Here …

Deafness or hearing loss is a major issue in human health. Inner ear hair cells are the main
sensory receptors responsible for hearing. Defects in hair cells are one of the major causes …

β-Thalassemia (β-Thal) is one of the most common genetic diseases in the world. The
generation of patient-specific β-Thal-induced pluripotent stem cells (iPSCs), correction of the …

Mesenchymal stem cells (MSC s) are being assessed for ameliorating the severity of graft‐
versus‐host disease, autoimmune conditions, musculoskeletal injuries and cardiovascular …

Background Tooth is vital not only for a good smile, but also good health. Yet, we lose tooth
regularly due to accidents or diseases. An ideal solution to this problem is to regenerate …

Abstract β-thalassemia results from point mutations or small deletions in the β-globin (HBB)
gene that ultimately cause anemia. The generation of induced pluripotent stem cells (iPSCs) …