Nucleic acid drugs: recent progress and future perspectives
X Sun, S Setrerrahmane, C Li, J Hu, H Xu - Signal Transduction and …, 2024 - nature.com
High efficacy, selectivity and cellular targeting of therapeutic agents has been an active area
of investigation for decades. Currently, most clinically approved therapeutics are small …
of investigation for decades. Currently, most clinically approved therapeutics are small …
Pre-clinical and clinical applications of small interfering RNAs (siRNA) and co-delivery systems for pancreatic cancer therapy
Pancreatic cancer (PC) is one of the leading causes of death and is the fourth most
malignant tumor in men. The epigenetic and genetic alterations appear to be responsible for …
malignant tumor in men. The epigenetic and genetic alterations appear to be responsible for …
Nanotechnology strategies to address challenges in topical and cellular delivery of siRNAs in skin disease therapy
AVP Silvestrini, MF Morais, BW Debiasi… - Advanced Drug Delivery …, 2024 - Elsevier
Gene therapy is one of the most advanced therapies in current medicine. In particular,
interference RNA-based therapy by small interfering RNA (siRNA) has gained attention in …
interference RNA-based therapy by small interfering RNA (siRNA) has gained attention in …
Cm-siRPred: Predicting chemically modified siRNA efficiency based on multi-view learning strategy
The rational modification of siRNA molecules is crucial for ensuring their drug-like
properties. Machine learning-based prediction of chemically modified siRNA (cm-siRNA) …
properties. Machine learning-based prediction of chemically modified siRNA (cm-siRNA) …
Circularized RNA as novel therapeutics in cancer
JJ Peña-Paladines, CH Wong, Y Chen - The International Journal of …, 2023 - Elsevier
Abstract Circular RNAs (CircRNAs) regulate gene expression by functioning as microRNA
sponges, regulating protein stability, and gilding proteins for gene transcription and …
sponges, regulating protein stability, and gilding proteins for gene transcription and …
Elimination of off-target effect by chemical modification of 5′-end of siRNA
Y Shiohama, R Fujita, M Sonokawa… - nucleic acid …, 2022 - liebertpub.com
In this study, the efficiency of RNA interference of small interfering RNAs (siRNAs) bearing
5′-O-methyl-2′-deoxythymidine (X) and 5′-amino-2′, 5′-dideoxythymidine (Z) at the …
5′-O-methyl-2′-deoxythymidine (X) and 5′-amino-2′, 5′-dideoxythymidine (Z) at the …
Exploring dose and downregulation dynamics in lipid nanoparticles based siRNA therapy: Systematic review and meta-analysis
Small interfering RNA (siRNA) holds promise as a therapeutic approach for various
diseases, yet challenges persist in achieving efficient delivery, biodistribution, and …
diseases, yet challenges persist in achieving efficient delivery, biodistribution, and …
[HTML][HTML] The Impact of Chemical Modifications on the Interferon-Inducing and Antiproliferative Activity of Short Double-Stranded Immunostimulating RNA
A Bishani, MI Meschaninova, MA Zenkova… - Molecules, 2024 - mdpi.com
A short 19 bp dsRNA with 3′-trinucleotide overhangs acting as immunostimulating RNA
(isRNA) demonstrated strong antiproliferative action against cancer cells …
(isRNA) demonstrated strong antiproliferative action against cancer cells …
Mechanistic analysis of the enhanced RNAi activity by 6-mCEPh-purine at the 5′ end of the siRNA guide strand
V Brechin, F Shinohara, J Saito, H Seitz, Y Tomari - RNA, 2021 - rnajournal.cshlp.org
A key approach for improving siRNA efficacy is chemical modifications. Through an in silico
screening of modifications at the 5′-end nucleobase of the guide strand, an adenine …
screening of modifications at the 5′-end nucleobase of the guide strand, an adenine …
Structure and Stability of Ago2 MID‐Nucleotide Complexes: All‐in‐One (Drop) His6‐SUMO Tag Removal, Nucleotide Binding, and Crystal Growth
The middle (MID) domain of eukaryotic Argonaute (Ago) proteins and archaeal and bacterial
homologues mediates the interaction with the 5′‐terminal nucleotide of miRNA and siRNA …
homologues mediates the interaction with the 5′‐terminal nucleotide of miRNA and siRNA …