[HTML][HTML] Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions

G Tse, JM Yeo - IJC Heart & Vasculature, 2015 - Elsevier
Ventricular arrhythmias arise from disruptions in the normal orderly sequence of electrical
activation and recovery of the heart. They can be categorized into disorders affecting …

Fibroblasts under pressure: cardiac fibroblast responses to hypertension and antihypertensive therapies

U Chalise, TM Hale - American Journal of Physiology-Heart …, 2024 - journals.physiology.org
Approximately 50% of Americans have hypertension, which significantly increases the risk of
heart failure. In response to increased peripheral resistance in hypertension, intensified …

Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats

J Monroy-Ruiz, MÁ Sevilla, R Carrón… - Pharmacological …, 2011 - Elsevier
The aim of this study was to investigate the effects of astaxanthin-enriched diet on blood
pressure, cardiac hypertrophy, both vascular structure and function and superoxide (O2−) …

Cardiac hypertrophy during hypercholesterolemia and its amelioration with rosuvastatin and amlodipine

BY Kang, W Wang, P Palade, SG Sharma… - Journal of …, 2009 - journals.lww.com
Hypercholesterolemia is a common accompaniment of atherosclerosis and may be
associated with cardiac hypertrophy. To define the mechanistic basis of cardiac hypertrophy …

The effects of velvet antler of deer on cardiac functions of rats with heart failure following myocardial infarction

MJ Shao, SR Wang, MJ Zhao, XL Lv… - Evidence‐Based …, 2012 - Wiley Online Library
Velvet antler of deer (VAD) is a commonly‐used kidney‐Yang supplementing traditional
Chinese medication. According to the heart‐kidney‐related theory, heart Yang originates in …

Efficacy of antihypertensive drugs of different classes after renal denervation in spontaneously hypertensive rats

M Hohl, L Lauder, Ö Sevimli, M Tokcan, L Wagmann… - …, 2023 - Am Heart Assoc
Background: Renal denervation (RDN) lowers blood pressure (BP) in patients with
uncontrolled hypertension. Limited data exist on the effectiveness of different …

Beneficial effects of combined benazepril-amlodipine on cardiac nitric oxide, cGMP, and TNF-α production after cardiac ischemia

HM Siragy, C Xue, RL Webb - Journal of cardiovascular …, 2006 - journals.lww.com
The aim of this study was to determine if myocardial inflammation is increased after
myocardial ischemia and whether angiotensin-converting enzyme inhibitors, calcium …

Persistent phenotypic shift in cardiac fibroblasts: impact of transient renin angiotensin system inhibition

TM Hale - Journal of molecular and cellular cardiology, 2016 - Elsevier
Fibrotic cardiac remodeling ultimately leads to heart failure—a debilitating and costly
condition. Select antihypertensive agents have been effective in reducing or slowing the …

Chronic treatment with pravastatin prevents early cardiovascular changes in spontaneously hypertensive rats

M Kassan, MJ Montero… - British journal of …, 2009 - Wiley Online Library
Background and purpose: This study investigates the effect of pravastatin on blood pressure,
cardiovascular remodelling and impaired endothelial function induced as early signs of …

TRPV4 regulates β1 integrin‐mediated cell–matrix adhesions and collagen remodeling

C Ji, Y Wang, Q Wang, A Wang, A Ali… - The FASEB …, 2023 - Wiley Online Library
Abstract Transient Receptor Potential Vanilloid‐type 4 (TRPV4) is a mechanosensitive,
Ca2+‐permeable plasma membrane channel that associates with focal adhesions …