Deconstructive functionalization involves carbon–carbon (C–C) bond cleavage followed by
bond construction on one or more of the constituent carbons. For example, ozonolysis and …

Deconstructive functionalizations involving scission of carbon-carbon double bonds are well
established. In contrast, unstrained C (sp3)–C (sp3) bond cleavage and functionalization …

Transition-metal-or oxidant-promoted deconstructive functionalizations of noncyclic carbon–
nitrogen bonds are well established, usually only leaving one moiety functionalized toward …

Chemical synthesis based on the skeletal variation has been prolifically utilized as an
attractive approach for modification of molecular properties. Given the ubiquity of unstrained …

Published data on ring opening reactions of nitrogen-containing cyclic compounds resulting
in various acyclic products are integrated and systematized. The reactions of common five …

Biosynthetic processes often involve reorganization of one family of natural products to
another. Chemical emulation of nature's rearrangement-based structural diversification …

Cleavage of inert C–N bonds in unstrained azacycles such as pyrrolidine remains a
formidable challenge in synthetic chemistry. To address this, we introduce an effective …

We report a strategy for the formal C− N cross‐coupling of tertiary amines via the in situ
generation and displacement of N‐acyl ammonium species. Specifically, treatment of …

Density functional calculations have provided evidence that a Ag (I)-mediated
deconstructive fluorination of N-benzoylated cyclic amines (LH) with Selectfluor [(F …

In this paper, selective cleavage and tunable functionalization of the inert C–C/C–N bonds in
N-arylpiperidines promoted by t BuONO under metal-free conditions is presented. To be …