Platelet-derived growth factors (PDGFs) and PDGF receptors (PDGFRs) are expressed in a
variety of tumors. Activation of the PDGF/PDGFR signaling pathway is associated with …

Excessive abnormal angiogenesis plays a pivotal role in tumor progression and is a
hallmark of solid tumors. This process is driven by an imbalance between pro-and anti …

Platelet-derived growth factors (PDGF) promotes cell proliferation, survival and migration,
primarily of cells of mesenchymal origin. Dysfunction of PDGF signaling has been observed …

The epidermal growth factor receptor (EGFR) was among the first receptor tyrosine kinases
(RTKs) for which ligand binding was studied and for which the importance of ligand-induced …

Tendon injuries cause prolonged disability and never recover completely. Current
mechanistic understanding of tendon regeneration is limited. Here, we use single-cell …

PDGFRA and PDGFRB are classical proto-oncogenes that encode receptor tyrosine kinases
responding to platelet-derived growth factor (PDGF). PDGFRA mutations are found in …

Abstract c-kit is a classical proto-oncogene that encodes a receptor tyrosine kinase (RTK)
that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell …

Platelet-derived growth factor (PDGF) was discovered as a serum-derived component
necessary for the growth of smooth muscle cells, fibroblasts, and glial cells. The PDGF family …

Platelet‐derived growth factor (PDGF) isoforms and their receptors have important roles
during embryogenesis, particularly in the development of various mesenchymal cell types in …

Asthma is a chronic and heterogenic disease of the respiratory system, one of the most
common lung diseases worldwide. The underlying pathologies, which are chronic …