Targeting Polycomb systems to regulate gene expression: modifications to a complex story
Polycomb group proteins are transcriptional repressors that are essential for normal gene
regulation during development. Recent studies suggest that Polycomb repressive …
regulation during development. Recent studies suggest that Polycomb repressive …
Sound of silence: the properties and functions of repressive Lys methyltransferases
C Mozzetta, E Boyarchuk, J Pontis… - Nature Reviews Molecular …, 2015 - nature.com
The methylation of histone Lys residues by Lys methyltransferases (KMTs) regulates
chromatin organization and either activates or represses gene expression, depending on …
chromatin organization and either activates or represses gene expression, depending on …
Genetic links between ovarian ageing, cancer risk and de novo mutation rates
Human genetic studies of common variants have provided substantial insight into the
biological mechanisms that govern ovarian ageing. Here we report analyses of rare protein …
biological mechanisms that govern ovarian ageing. Here we report analyses of rare protein …
A high-density map for navigating the human polycomb complexome
Polycomb group (PcG) proteins are major determinants of gene silencing and epigenetic
memory in higher eukaryotes. Here, we systematically mapped the human PcG complexome …
memory in higher eukaryotes. Here, we systematically mapped the human PcG complexome …
Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes
Aging associates with impaired pancreatic islet function and increased type 2 diabetes
(T2D) risk. Here we examine whether age-related epigenetic changes affect human islet …
(T2D) risk. Here we examine whether age-related epigenetic changes affect human islet …
The dynamic interactome and genomic targets of Polycomb complexes during stem-cell differentiation
SL Kloet, MM Makowski, HI Baymaz… - Nature structural & …, 2016 - nature.com
Although the core subunits of Polycomb group (PcG) complexes are well characterized, little
is known about the dynamics of these protein complexes during cellular differentiation. We …
is known about the dynamics of these protein complexes during cellular differentiation. We …
PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing
PALI1 is a newly identified accessory protein of the Polycomb repressive complex 2 (PRC2)
that catalyzes H3K27 methylation. However, the roles of PALI1 in cancer are yet to be …
that catalyzes H3K27 methylation. However, the roles of PALI1 in cancer are yet to be …
A dual role for PSIP1/LEDGF in T cell acute lymphoblastic leukemia
L Demoen, F Matthijssens, L Reunes, B Palhais… - Science …, 2024 - science.org
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy.
Current intensified therapeutic protocols coincide with severe side effects, and no salvage …
Current intensified therapeutic protocols coincide with severe side effects, and no salvage …
EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells
R Ragazzini, R Pérez-Palacios, IH Baymaz… - Nature …, 2019 - nature.com
The Polycomb group of proteins is required for the proper orchestration of gene expression
due to its role in maintaining transcriptional silencing. It is composed of several chromatin …
due to its role in maintaining transcriptional silencing. It is composed of several chromatin …
G9a/GLP complex maintains imprinted DNA methylation in embryonic stem cells
T Zhang, A Termanis, B Özkan, XX Bao, J Culley… - Cell reports, 2016 - cell.com
DNA methylation at imprinting control regions (ICRs) is established in gametes in a sex-
specific manner and has to be stably maintained during development and in somatic cells to …
specific manner and has to be stably maintained during development and in somatic cells to …