Radioresistance in Glioblastoma and the Development of Radiosensitizers

MY Ali, CR Oliva, ASM Noman, BG Allen, PC Goswami… - Cancers, 2020 - mdpi.com
Simple Summary Numerous mechanisms of glioblastoma (GBM) radioresistance have been
identified but have not yet resulted in development of effective radiosensitizer that can …

Crosstalk between apoptosis and autophagy: molecular mechanisms and therapeutic strategies in cancer

A El-Khattouti, D Selimovic, Y Haikel… - Journal of cell …, 2013 - journals.sagepub.com
Both apoptosis and autophagy are highly conserved processes that besides their role in the
maintenance of the organismal and cellular homeostasis serve as a main target of tumor …

Glutathione depletion sensitizes cisplatin-and temozolomide-resistant glioma cells in vitro and in vivo

CRR Rocha, CCM Garcia, DB Vieira, A Quinet… - Cell death & …, 2014 - nature.com
Malignant glioma is a severe type of brain tumor with a poor prognosis and few options for
therapy. The main chemotherapy protocol for this type of tumor is based on temozolomide …

Honey bee venom melittin increases the oxidant activity of cisplatin and kills human glioblastoma cells by stimulating the TRPM2 channel

K Ertilav, M Nazıroğlu - Toxicon, 2023 - Elsevier
Melittin (MLT) treatment is believed to enhance tumor cell death, apoptotic, and oxidative
cytotoxic effects of cisplatin (CSP) via the modulation of Ca 2+ channels in several cancer …

A HIF-independent, CD133-mediated mechanism of cisplatin resistance in glioblastoma cells

EM Ahmed, G Bandopadhyay, B Coyle, A Grabowska - Cellular Oncology, 2018 - Springer
Purpose Glioblastoma (GBM) is the commonest brain tumour in adults. A sub-population of
cells within these tumours, known as cancer stem cells (CSCs), is thought to mediate their …

BK channels blockage inhibits hypoxia‐induced migration and chemoresistance to cisplatin in human glioblastoma cells

P Rosa, L Catacuzzeno, L Sforna… - Journal of Cellular …, 2018 - Wiley Online Library
Glioblastoma (GBM) cells express large‐conductance, calcium‐activated potassium (BK)
channels, whose activity is important for several critical aspects of the tumor, such as …

Self-assembled 20-nm 64Cu-micelles enhance accumulation in rat glioblastoma

JW Seo, JC Ang, LM Mahakian, S Tam, B Fite… - Journal of Controlled …, 2015 - Elsevier
There is an urgent need to develop nanocarriers for the treatment of glioblastoma multiforme
(GBM). Using co-registered positron emission tomography (PET) and magnetic resonance …

Histone deacetylase inhibitors impair vasculogenic mimicry from glioblastoma cells

O Pastorino, MT Gentile, A Mancini, N Del Gaudio… - Cancers, 2019 - mdpi.com
Glioblastoma (GBM), a high-grade glioma (WHO grade IV), is the most aggressive form of
brain cancer. Available treatment options for GBM involve a combination of surgery …

Ruta graveolens L. Induces Death of Glioblastoma Cells and Neural Progenitors, but Not of Neurons, via ERK 1/2 and AKT Activation

MT Gentile, C Ciniglia, MG Reccia, F Volpicelli… - PLoS …, 2015 - journals.plos.org
Glioblastoma multiforme is a highly aggressive brain tumor whose prognosis is very poor.
Due to early invasion of brain parenchyma, its complete surgical removal is nearly …

Let-7b expression determines response to chemotherapy through the regulation of cyclin D1 in glioblastoma

Y Guo, K Yan, J Fang, Q Qu, M Zhou… - Journal of Experimental & …, 2013 - Springer
Background Glioblastoma is the most common type of primary brain tumors. Cisplatin is a
commonly used chemotherapeutic agent for Glioblastoma patients. Despite a consistent rate …