New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN
A Monteil, NC Guérineau, A Gil-Nagel… - Physiological …, 2024 - journals.physiology.org
Cell excitability and its modulation by hormones and neurotransmitters involve the concerted
action of a large repertoire of membrane proteins, especially ion channels. Unique …
action of a large repertoire of membrane proteins, especially ion channels. Unique …
Structural pharmacology of voltage-gated sodium channels
S Noreng, T Li, J Payandeh - Journal of Molecular Biology, 2021 - Elsevier
Voltage-gated sodium (Na V) channels initiate and propagate action potentials in excitable
tissues to mediate key physiological processes including heart contraction and nervous …
tissues to mediate key physiological processes including heart contraction and nervous …
Structural architecture of the human NALCN channelosome
Depolarizing sodium (Na+) leak currents carried by the NALCN channel regulate the resting
membrane potential of many neurons to modulate respiration, circadian rhythm, locomotion …
membrane potential of many neurons to modulate respiration, circadian rhythm, locomotion …
Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex
NALCN channel mediates sodium leak currents and is important for maintaining proper
resting membrane potential. NALCN and FAM155A form the core complex of the channel …
resting membrane potential. NALCN and FAM155A form the core complex of the channel …
Applications of Cryo-EM in small molecule and biologics drug design
Electron cryo-microscopy (cryo-EM) is a powerful technique for the structural
characterization of biological macromolecules, enabling high-resolution analysis of targets …
characterization of biological macromolecules, enabling high-resolution analysis of targets …
The Na+/K+ pump dominates control of glycolysis in hippocampal dentate granule cells
DJ Meyer, CM Díaz-García, N Nathwani, M Rahman… - Elife, 2022 - elifesciences.org
Cellular ATP that is consumed to perform energetically expensive tasks must be replenished
by new ATP through the activation of metabolism. Neuronal stimulation, an energetically …
by new ATP through the activation of metabolism. Neuronal stimulation, an energetically …
The chemistry of electrical signaling in sodium channels from bacteria and beyond
WA Catterall, TMG El-Din, G Wisedchaisri - Cell Chemical Biology, 2024 - cell.com
Electrical signaling is essential for all fast processes in biology, but its molecular
mechanisms have been uncertain. This review article focuses on studies of bacterial sodium …
mechanisms have been uncertain. This review article focuses on studies of bacterial sodium …
Structural basis for Ca2+ activation of the heteromeric PKD1L3/PKD2L1 channel
The heteromeric complex between PKD1L3, a member of the polycystic kidney disease
(PKD) protein family, and PKD2L1, also known as TRPP2 or TRPP3, has been a prototype …
(PKD) protein family, and PKD2L1, also known as TRPP2 or TRPP3, has been a prototype …
Structure of the human sodium leak channel NALCN in complex with FAM155A
J Xie, M Ke, L Xu, S Lin, J Huang, J Zhang… - Nature …, 2020 - nature.com
NALCN, a sodium leak channel expressed mainly in the central nervous system, is
responsible for the resting Na+ permeability that controls neuronal excitability. Dysfunctions …
responsible for the resting Na+ permeability that controls neuronal excitability. Dysfunctions …
Architecture of the human NALCN channelosome
NALCN regulates the resting membrane potential by mediating the Na+ leak current in
neurons, and it functions as a channelosome in complex with FAM155A, UNC79, and …
neurons, and it functions as a channelosome in complex with FAM155A, UNC79, and …