Evolving studies with several different targeted therapeutic agents are demonstrating that
patients with genomic alterations of the target, including amplification, translocation and …

Combinatorial control of biological processes, in which redundancy and multifunctionality
are the norm, fundamentally limits the therapeutic index that can be achieved by even the …

Genome sequences are now available that enable us to determine the biological
components that make up a cell or an organism. The discipline of systems biology examines …

The phosphoinositide 3‐OH kinase (PI3K)/Akt pathway has been implicated in regulating
several important cellular processes, including apoptosis, survival, proliferation, and …

Cell migration directed by spatial cues, or taxis, is a primary mechanism for orchestrating
concerted and collective cell movements during development, wound repair, and immune …

The p110 isoforms of phosphoinositide 3-kinase (PI3K) are acutely regulated by
extracellular stimuli. The class IA PI3K catalytic subunits (p110α, p110β, and p110δ) occur in …

Multi-component signal transduction pathways and gene regulatory circuits underpin
integrated cellular responses to perturbations. A recurring set of network motifs serve as the …

We report a new technique called Digital microfluidic Immunocytochemistry in Single Cells
(DISC). DISC automates protocols for cell culture, stimulation and immunocytochemistry …

Several cytokine families have roles in the development, maintenance, and remodeling of
the microcirculation. Of these, the vascular endothelial growth factor (VEGF) family is one of …

Global inhibition of class I and II histone deacetylases (HDACs) impairs angiogenesis.
Herein, we have undertaken the identification of the specific HDAC (s) with activity that is …