This review intends to summarize the structures of an extensive number of symmetrical-
dimeric drugs, having two monomers, linked via a bridging entity emphasizing the versatility …

Five dimeric oleanolic acids linked at C-28 by 1, 6-hexanediamine, or built around the
carbon chains of varying lengths between two carboxyl groups were synthesized, to …

Nitrogen-containing heterocycles are one of the most common structural motifs in
approximately 80% of the marketed drugs. Of these, benzimidazoles analogues are known …

Dimeric bis-benzimidazoles (DBn) are the compounds specifically binding to A–T enriched
sequences in the DNA minor groove. Due to this property they can inhibit DNA-dependent …

Бензимидазол является фундаментальным фармакофором при создании лекарств из-
за его широкого спектра биологической активности. Синтезированы новые АТ …

Its broad spectrum of biological activity makes benzimidazole a fundamental
pharmacophore in pharmaceutics. The paper describes newly synthesized AT-specific …

Purpose of the study was search for agents to eliminate the pool of cancer stem cells (CSCs)
and increase their radiosensitivity among DNA minor groove binding ligands, synthetic …

A new series of AT-specific minor groove DNA ligands (DB3P (n); n= 1, 2, 3, 4) was
synthesized and their spectral, biological and virological properties were investigated. With …

Cancer cells are characterized by hypermethylation of the promoter regions of tumor
suppressor genes. DNA methyltransferase inhibitors reactivate the genes, pointing to DNA …

Seven fluorescent symmetric dimeric bisbenzimidazoles DB (n) capable of occupying up to
one turn of the double-stranded B-form DNA have been designed and synthesized with the …