Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Nanopipettes provide a promising confined space that enables advances in
electrochemical, optical, and mass spectrometric measurements at the nanoscale. They …

Gene editing is a versatile technique in biomedicine that promotes fundamental research as
well as clinical therapy. The development of Clustered Regularly Interspaced Short …

Cation-π interactions arise as a result of strong attractive forces between positively charged
entities and the π-electron cloud of aromatic groups. The physicochemical characteristics of …

Effective tumor regression has been observed with chimeric antigen receptor (CAR) T cells;
however, the development of an affordable, safe, and effective CAR-T cell treatment remains …

Manipulation of cells for applications such as biomanufacturing and cell-based therapeutics
involves introducing biomolecular cargoes into cells. However, successful delivery is a …

Innate cell function can be artificially engineered and reprogrammed by introducing
biomolecules, such as DNAs, RNAs, plasmid DNAs, proteins, or nanomaterials, into the …

Establishing techniques to efficiently and nondestructively access the intracellular milieu is
essential for many biomedical and scientific applications, ranging from drug delivery, to …

One-dimensional nanoneedle-like arrays have emerged as an attractive tool for penetrating
the cell membrane to achieve intracellular applications including drug delivery, electrical …

Precision medicine requires precise regulation of drugs in terms of time, space, and dosage.
Exogenous control systems, such as electrical responsiveness, have made great progress …