Inherited haemoglobin disorders, including thalassaemia and sickle-cell disease, are the
most common monogenic diseases worldwide. Several clinical forms of α-thalassaemia and …

Patients suffering from iron overload can experience serious complications. In such patients,
various organs, such as endocrine glands and liver, can be damaged. Although iron is a …

Thalassemic disorders lie on a phenotypic spectrum of clinical severity that depends on the
severity of the globin gene mutation and coinheritance of other genetic determinants. Iron …

β-Thalassemias Defective synthesis of the β-globin chain causes recessively inherited
disorders characterized by inadequate hemoglobin production and chronic anemia …

Iron overload is a common clinical problem, arising from disorders of increased iron
absorption such as hereditary haemochromatosis or thalassaemia intermedia syndromes or …

The complex pathophysiology in β-thalassemia can translate to multiple morbidities that
affect every organ system. Improved survival due to advances in management means that …

Patients with β-thalassemia major (TM) and other refractory anemias requiring regular blood
transfusions accumulate iron that damages the liver, endocrine system, and most importantly …

Iron overload is a pathological condition resulting from a congenital impairment of its
regulation, increased intestinal iron absorption secondary to bone marrow erythroid …

Nitric oxide (NO) generated by inducible NO synthase 2 (NOS2) affects cellular iron
homeostasis, but the underlying molecular mechanisms and implications for NOS2 …

Significance: Under normal circumstances, cellular iron levels are tightly regulated due to
the potential toxic effects of this metal ion. There is evidence that tumors possess altered iron …