Diarthrodial joints are well suited to intra-articular injection, and the local delivery of
therapeutics in this fashion brings several potential advantages to the treatment of a wide …

Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an
important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage …

The purpose of this study was to investigate the influence of moderate physical activity
(MPA) on the expression of osteoarthritis (OA)-related (IL-1β, IL-6, TNF-α, MMP-13) and anti …

Osteoarthritis (OA), the most common of all arthropathies, is a leading cause of disability and
has a large (and growing) worldwide socioeconomic cost. Despite its burgeoning …

Osteoarthritis is a complex disease involving the mechanical breakdown of articular
cartilage in the presence of altered joint mechanics and chondrocyte death, but the …

Objective Hypocellularity resulting from chondrocyte death in the aftermath of mechanical
injury is thought to contribute to posttraumatic osteoarthritis. However, we observed that …

When lubricated by synovial fluid, articular cartilage provides some of the lowest friction
coefficients found in nature. While it is known that macromolecular constituents of synovial …

Abstract Background Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted
by synovial fibroblasts and superficial zone chondrocytes. PRG4 has a homeostatic …

Objective To evaluate the binding of recombinant human proteoglycan 4 (rhPRG4) to CD44
receptor and its consequences on cytokine‐induced synoviocyte proliferation. Methods The …

Mediterranean diet includes a relatively high fat consumption mostly from monounsaturated
fatty acids mainly provided by olive oil, the principal source of culinary and dressing fat. The …