The ubiquitin-proteasome system (UPS) is involved in multiple aspects of cellular processes,
such as cell cycle progression, cellular differentiation, and survival (Davis RJ et al., Cancer …

Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …

T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of
hematopoietic progenitors primed toward T cell development, as result of a multistep …

Acute lymphoblastic leukemia (ALL) is a disseminated malignancy of B-or T-lymphoblasts
which imposes a rapid and accurate diagnostic process to support an optimal risk-oriented …

The biology and outcome of adult T-cell acute lymphoblastic leukemia are poorly
understood. We present here the clinical and biologic features of 356 patients treated …

T-cell acute lymphoblastic leukemias (T-ALL) are immature lymphoid tumors localizing in the
bone marrow, mediastinum, central nervous system, and lymphoid organs. They account for …

T-cell immunophenotype of acute lymphoblastic leukemia (T-ALL) is an uncommon
aggressive leukemia that can present with leukemic and/or lymphomatous manifestations …

Chromosomal abnormalities are established prognostic markers in adult ALL. We assessed
the prognostic impact of established chromosomal abnormalities and key copy number …

T-cell acute lymphoblastic leukemia (ALL) is a rare disease in adults with inferior survival
outcomes compared with those seen in pediatric patients. Although potentially curable …

Significant improvements have been made in the treatment of acute lymphoblastic leukemia
(ALL) during the past 2 decades, and measurement of submicroscopic (minimal) levels of …