The p53 tumor suppressor protein has a plethora of cell-intrinsic functions and
consequences that impact diverse cell types and tissues. Recent studies are beginning to …

The cascade of metastasis in tumor cells, exhibiting organ-specific tendencies, may occur at
numerous phases of the disease and progress under intense evolutionary pressures. Organ …

Genomic instability, a hallmark of cancer, is a direct consequence of the inactivation of the
tumor suppressor protein p53. Genetically modified mouse models and human tumor …

Mutations in the p53 gene compromise its role as guardian of genomic integrity, yielding
predominantly missense p53 mutant proteins. The gain-of-function hypothesis has long …

Simple Summary p53 mutations are prevalent across a variety of human cancers and are
regarded as a major obstacle in cancer therapy. These mutations can confer resistance to …

Summary p53 was discovered 45 years ago as an SV40 large T antigen binding protein,
coded by the most frequently mutated TP53 gene in human cancers. As a transcription …

Background The protein p53, encoded by the most frequently mutated gene TP53 in human
cancers, has diverse functions in tumor suppression. As a best known transcription factor …

Although aberrant activation of the KRAS and PI3K pathway alongside TP53 mutations
account for frequent aberrations in human gastric cancers, neither the sequence nor the …

Metastasis is the primary cause of cancer-related death, with the dissemination and
colonization of primary tumor cells at the metastatic site facilitated by various molecules and …

Macrophages are myeloid cells that receive, integrate, and respond to tumoral cues. Tumors
evolve and are shaped by macrophages, with tumor-associated macrophage (TAM)-tumor …