Interleukin-7 (IL-7) is a multipotent cytokine that maintains the homeostasis of the immune
system. IL-7 plays a vital role in T-cell development, proliferation, and differentiation, as well …

Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene are often present in newly
diagnosed acute myeloid leukemia (AML) patients with an incidence rate of approximately …

Our study details the stepwise evolution of gilteritinib resistance in FLT3-mutated acute
myeloid leukemia (AML). Early resistance is mediated by the bone marrow …

Bone morphogenetic proteins (BMPs) are secreted cytokines that control the fate and
function of many different cell types. They exert their cellular responses via heteromeric …

Acute myeloid leukemia remains associated with poor outcomes despite advances in our
understanding of the complicated molecular events driving leukemogenesis and malignant …

The bone marrow (BM) provides a protective microenvironment to support the survival of
leukemic cells and influence their response to therapeutic agents. In acute myeloid leukemia …

The identification of recurrent driver mutations in genes encoding tyrosine kinases has
resulted in the development of molecularly-targeted treatment strategies designed to …

Internal tandem duplication (ITD) of the fms-like tyrosine kinase 3 (FLT3) gene is a gain-of-
function mutation common in acute myeloid leukaemia (AML). It is associated with inferior …

Development of chemoresistance, which limits the efficiency of anticancer agents, has long
been a major problem in cancer therapy and urgently needs to be solved to improve clinical …

Acute myeloid leukemia (AML) is sustained by small populations of leukemia stem cells
(LSCs) that can resist available treatments and represent important barriers to cure …