Applications of radiocomplexes with thiosemicarbazones and bis (thiosemicarbazones) in diagnostic and therapeutic nuclear medicine

GL Parrilha, RG dos Santos, H Beraldo - Coordination Chemistry Reviews, 2022 - Elsevier
Metallic radionuclides possess a variety of half-lives, emission types, energies, and
branching ratios, making it possible to apply them as diagnostic and/or therapeutic agents …

Development and prospects of dedicated tracers for the molecular imaging of bacterial infections

A Bunschoten, MM Welling, MF Termaat… - Bioconjugate …, 2013 - ACS Publications
Bacterial infections have always been, and still are, a major global healthcare problem. For
accurate treatment it is of upmost importance that the location (s), severity, type of bacteria …

Highlights of the latest developments in radiopharmaceuticals for infection imaging and future perspectives

E Dadachova, DEN Rangel - Frontiers in Medicine, 2022 - frontiersin.org
COVID-19 pandemic has heightened the interest toward diagnosis and treatment of
infectious diseases. Nuclear medicine with its powerful scintigraphic, single photon emission …

Synthesis, characterization and biological evaluation of 99mTc/Re–tricarbonyl quinolone complexes

TE Kydonaki, E Tsoukas, F Mendes… - Journal of Inorganic …, 2016 - Elsevier
New rhenium (I) tricarbonyl complexes with the quinolone antimicrobial agents oxolinic acid
(Hoxo) and enrofloxacin (Herx) and containing methanol, triphenylphosphine (PPh 3) or …

Bacterial production of ciprofloxacin and potential usage as a radiotracer

KB Karatay, N Dogruoz Gungor, B Colak… - Plos One, 2023 - journals.plos.org
Infectious diseases caused by bacteria that have become resistant to antibiotics have
increased in prevalence, necessitating new methods for their diagnosis and treatment. The …

Hexadentate technetium-99m bis (thiosemicarbazonato) complexes: synthesis, characterisation and biodistribution

CAA Kelderman, PRWJ Davey, MT Ma, M de Veer… - Dalton …, 2022 - pubs.rsc.org
The syntheses of non-oxido/non-nitrido bis (thiosemicarbazonato) technetium (V) complexes
featuring a series of alkyl and ether substituents is presented. The bis (thiosemicarbazones) …

Physicochemical and Biological Study of 99mTc and 68Ga Radiolabelled Ciprofloxacin and Evaluation of [99mTc]Tc-CIP as Potential Diagnostic …

P Koźmiński, W Gawęda, M Rzewuska, A Kopatys… - Tomography, 2021 - mdpi.com
This paper presents the application of ciprofloxacin as a biologically active molecule (vector)
for delivering diagnostic radiopharmaceuticals to the sites of bacterial infection …

68Ga‐labeled Ciprofloxacin Conjugates as Radiotracers for Targeting Bacterial Infection

D Satpati, C Arjun, R Krishnamohan… - Chemical Biology & …, 2016 - Wiley Online Library
With an aim of developing a bacteria‐specific molecular imaging agent, ciprofloxacin has
been modified with a propylamine spacer and linked to two common bifunctional chelators …

Influence of ligand denticity on the properties of novel 99mTc (I)–carbonyl complexes. Application to the development of radiopharmaceuticals for imaging hypoxic …

S Fernández, J Giglio, AM Rey, H Cerecetto - Bioorganic & medicinal …, 2012 - Elsevier
An important issue in the development of metal-based radiopharmaceuticals is the selection
of the labelling strategy in order to couple the metal to the pharmacophore without losing the …

Technetium-99m based small molecule radiopharmaceuticals and radiotracers targeting inflammation and infection

T Kniess, M Laube, F Wüst, J Pietzsch - Dalton transactions, 2017 - pubs.rsc.org
In nuclear medicine, the detection of inflamed and infected lesions is of growing interest.
Extensive efforts have been made to develop radiopharmaceuticals specific for inflammation …