The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate-N-acetyl
glucosamine, UDP-GlcNAc, which is a key metabolite that is used for N-or O-linked …

The presence of fucose on IgG1 Asn-297 N-linked glycan is the modification of the human
IgG1 Fc structure with the most significant impact on FcɣRIII affinity. It also significantly …

Activation of the IRE1/XBP1s signaling arm of the unfolded protein response (UPR) is a
promising strategy to correct defects in endoplasmic reticulum (ER) proteostasis implicated …

N-linked glycosylation is a complex, co-and post-translational series of events that connects
metabolism to signaling in almost all cells. Metabolic assembly of N-linked glycans spans …

The endoplasmic reticulum (ER) is commonly referred to as the factory of the cell, as it is
responsible for a large amount of protein and lipid synthesis. As a membrane-bound …

A code is defined by the nature of the symbols, which are used to generate information‐
storing combinations (eg oligo‐and polymers). Like nucleic acids and proteins, oligo‐and …

Glycans play critical roles in cellular signaling and function. Unlike proteins, glycan
structures are not templated from genetic sequences but synthesized by the concerted …

Influenza virus infections cause a wide variety of outcomes, from mild disease to 3 to 5
million cases of severe illness and∼ 290,000 to 645,000 deaths annually worldwide. The …

Understanding the factors that shape viral evolution is critical for developing effective
antiviral strategies, accurately predicting viral evolution, and preventing pandemics. One …

Background: Unfolded protein response (UPR) is a multifaceted signaling cascade that
alleviates protein misfolding. Although well studied in nucleated cells, UPR in absence of …