Bacterial secretion systems: an overview

ER Green, J Mecsas - Virulence mechanisms of bacterial …, 2016 - Wiley Online Library
One essential prokaryotic cell function is the transport of proteins from the cytoplasm into
other compartments of the cell, the environment, and/or other bacteria or eukaryotic cells—a …

Advances in understanding bacterial outer-membrane biogenesis

N Ruiz, D Kahne, TJ Silhavy - Nature Reviews Microbiology, 2006 - nature.com
The outer membrane of Gram-negative bacteria such as Escherichia coli serves as a
protective barrier that controls the influx and efflux of solutes. This allows the bacteria to …

Release of outer membrane vesicles by Gram‐negative bacteria is a novel envelope stress response

AJ McBroom, MJ Kuehn - Molecular microbiology, 2007 - Wiley Online Library
Conditions that impair protein folding in the Gram‐negative bacterial envelope cause stress.
The destabilizing effects of stress in this compartment are recognized and countered by a …

Defining the roles of the periplasmic chaperones SurA, Skp, and DegP in Escherichia coli

JG Sklar, T Wu, D Kahne, TJ Silhavy - Genes & development, 2007 - genesdev.cshlp.org
Integral β-barrel proteins (OMPs) are a major class of outer membrane proteins in Gram-
negative bacteria. In Escherichia coli, these proteins are synthesized in the cytoplasm …

β-Barrel membrane protein assembly by the Bam complex

CL Hagan, TJ Silhavy, D Kahne - Annual review of biochemistry, 2011 - annualreviews.org
β-barrel membrane proteins perform important functions in the outer membranes (OMs) of
Gram-negative bacteria and of the mitochondria and chloroplasts of eukaryotes. The protein …

Identification of a protein complex that assembles lipopolysaccharide in the outer membrane of Escherichia coli

T Wu, AC McCandlish… - Proceedings of the …, 2006 - National Acad Sciences
The outer membrane of most Gram-negative bacteria is made up of LPS, and in nearly all
bacteria that contain LPS it is essential for the life of the organism. The lipid portion of this …

Reconstitution of outer membrane protein assembly from purified components

CL Hagan, S Kim, D Kahne - Science, 2010 - science.org
β-barrel membrane proteins in Gram-negative bacteria, mitochondria, and chloroplasts are
assembled by highly conserved multi-protein complexes. The mechanism by which these …

Structure and function of an essential component of the outer membrane protein assembly machine

S Kim, JC Malinverni, P Sliz, TJ Silhavy, SC Harrison… - Science, 2007 - science.org
Integral β-barrel proteins are found in the outer membranes of mitochondria, chloroplasts,
and Gram-negative bacteria. The machine that assembles these proteins contains an …

YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli

JC Malinverni, J Werner, S Kim, JG Sklar… - Molecular …, 2006 - Wiley Online Library
Recent advances in the study of bacterial membranes have led to the identification of a
multicomponent YaeT complex in the outer membrane (OM) of Gram‐negative bacteria that …

Bacterial protein secretion through the translocase nanomachine

E Papanikou, S Karamanou, A Economou - Nature Reviews …, 2007 - nature.com
All cells must traffic proteins across their membranes. This essential process is responsible
for the biogenesis of membranes and cell walls, motility and nutrient scavenging and uptake …