Maturation of neuronal circuits requires selective elimination of synaptic connections.
Although neuron-intrinsic mechanisms are important in this process, it is increasingly …

A new and powerful approach, called imaging-wide association study (IWAS), is proposed to
integrate imaging endophenotypes with GWAS to boost statistical power and enhance …

Motivation. At present, the research methods for image genetics of Alzheimer's disease
based on machine learning are mainly divided into three steps: the first step is to preprocess …

Testing for genetic association with multiple traits has become increasingly important, not
only because of its potential to boost statistical power, but also for its direct relevance to …

Neuroinflammation plays an important role in the induction and maintenance of chronic
pain. Orchestra of pattern-recognition receptor-induced pro-inflammatory and anti …

Identification of genetic factors leading to increased risk of suicide death is critical to combat
rising suicide rates, however, only a fraction of the genetic variation influencing risk has …

Alzheimer's disease (AD) is a complex neurodegenerative condition that is clinically
characterized by impaired cognitive functions. The major morphologically observed lesion of …

Unbiased genetic association studies, including genome-wide association and whole-
genome sequencing studies, have uncovered many novel disease-associated variants …

Motivation: At present, a number of correlation analysis methods between SNPs and ROIs
have been devised to explore the pathogenic mechanism of Alzheimer's disease. However …

RNA interference (RNAi), including microRNAs, is an important player in the mediation of
differentiation and migration of stem cells via target genes. It is used as a potential strategy …