Decades of research in skeletal muscle physiology have provided multiscale insights into
the structural and functional complexity of this important anatomical tissue, designed to …

▪ Abstract We describe the formation, maturation, elimination, maintenance, and
regeneration of vertebrate neuromuscular junctions (NMJs), the best studied of all synapses …

Syncytial skeletal muscle cells contain hundreds of nuclei in a shared cytoplasm. We
investigated nuclear heterogeneity and transcriptional dynamics in the uninjured and …

Human induced pluripotent stem cells (iPSC) hold promise for modeling diseases in
individual human genetic backgrounds and thus for developing precision medicine. Here …

Injuries to the adult CNS often result in permanent disabilities because neurons lose the
ability to regenerate their axon during development. Here, whole transcriptome sequencing …

Synapses, as fundamental units of the neural circuitry, enable complex behaviors. The
neuromuscular junction (NMJ) is a synapse type that forms between motoneurons and …

Formation of neuromuscular synapses requires a series of inductive interactions between
growing motor axons and differentiating muscle cells, culminating in the precise …

We examine the role of synaptic activity in the development of identified Drosophila
embryonic motorneurons. Synaptic activity was blocked by both pan-neuronal expression of …

During neuromuscular synapse formation, motor axons induce clustering of acetylcholine
receptors (AChRs) in the muscle fiber membrane. The protein agrin, originally isolated from …

To elucidate molecular mechanisms underlying activity-dependent synaptic remodeling in
the developing mammalian visual system, we screened for genes whose expression in the …