Global epidemiology and burden of HCV infection and HCV-related disease

AP Thrift, HB El-Serag, F Kanwal - Nature reviews Gastroenterology & …, 2017 - nature.com
Chronic HCV infection is a global health problem that affects> 184 million people worldwide.
HCV is associated with several hepatic and extrahepatic disorders, including several …

Epidemiological and etiological variations in hepatocellular carcinoma

E Sagnelli, M Macera, A Russo, N Coppola, C Sagnelli - Infection, 2020 - Springer
Background Hepatocellular carcinoma (HCC) is the most prevalent form of liver cancer and
a leading cause of cancer-related deaths worldwide. The major risk factors for HCC …

Eradication of hepatitis C virus infection in patients with cirrhosis reduces risk of liver and non-liver complications

P Nahon, V Bourcier, R Layese, E Audureau, C Cagnot… - Gastroenterology, 2017 - Elsevier
Background & Aims We performed a prospective study to investigate the effects of a
sustained viral response (SVR) on outcomes of patients with hepatitis C virus (HCV) …

Toward a more accurate estimate of the prevalence of hepatitis C in the United States

BR Edlin, BJ Eckhardt, MA Shu, SD Holmberg… - Hepatology, 2015 - journals.lww.com
Abstract Data from the 2003‐2010 National Health and Nutrition Examination Survey
(NHANES) indicate that about 3.6 million people in the United States have antibodies to the …

[PDF][PDF] 17‐beta hydroxysteroid dehydrogenase 13 is a hepatic retinol dehydrogenase associated with histological features of nonalcoholic fatty liver disease

Y Ma, OV Belyaeva, PM Brown, K Fujita, K Valles… - …, 2019 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. A
single‐nucleotide polymorphism (SNP), rs6834314, was associated with serum liver …

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

K Gariani, KJ Menzies, D Ryu, CJ Wegner… - …, 2016 - Wiley Online Library
With no approved pharmacological treatment, nonalcoholic fatty liver disease (NAFLD) is
now the most common cause of chronic liver disease in Western countries and its worldwide …

Cost-effectiveness and budget impact of hepatitis C virus treatment with sofosbuvir and ledipasvir in the United States

J Chhatwal, F Kanwal, MS Roberts… - Annals of internal …, 2015 - acpjournals.org
Background: Sofosbuvir and ledipasvir, which have recently been approved for treatment of
chronic hepatitis C virus (HCV) infection, are more efficacious and safer than the old …

Prevention of hepatitis C by screening and treatment in US prisons

T He, K Li, MS Roberts, AC Spaulding… - Annals of internal …, 2016 - acpjournals.org
Background: The prevalence of hepatitis C virus (HCV) in US prisoners is high; however,
HCV testing and treatment are rare. Infected inmates released back into society contribute to …

[PDF][PDF] Hepatitis C disease burden in the United States in the era of oral direct‐acting antivirals

J Chhatwal, X Wang, T Ayer, M Kabiri, RT Chung… - …, 2016 - Wiley Online Library
Oral direct‐acting antivirals (DAAs) represent a major advance in hepatitis C virus (HCV)
treatment. Along with recent updates in HCV screening policy and expansions in insurance …

Elevated alpha-fetoprotein: differential diagnosis-hepatocellular carcinoma and other disorders

RJ Wong, A Ahmed, RG Gish - Clinics in liver disease, 2015 - liver.theclinics.com
Globally, up to approximately 800,000 new cases of hepatocellular carcinoma (HCC) are
diagnosed annually. 1, 2 The incidence of cirrhosis-related HCC is rising in the United …