Axon outgrowth and guidance to the proper target requires the coordination of filamentous
(F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape …

The ubiquitously expressed phosphoinositide 3-kinase (PI3K) family of lipid kinases control
diverse cellular functions including cell survival, proliferation, metabolism and migration …

Rap1 small GTPases interact with Rap1-GTP-interacting adaptor molecule (RIAM), a
member of the MRL (Mig-10/RIAM/Lamellipodin) protein family, to promote talin-dependent …

Ena/VASP proteins and the WAVE regulatory complex (WRC) regulate cell motility by virtue
of their ability to independently promote actin polymerization. We demonstrate that …

The correct wiring of neuronal circuits depends on outgrowth and guidance of neuronal
processes during development. In the past two decades, great progress has been made in …

In the developing nervous system, nerve cells and axons respond to various attractive and
repulsive guidance cues while traveling to their final destination. Netrins are bifunctional …

The emergence of neurites from a symmetrical cell body is an essential feature of nervous
system development. Neurites are the precursors of axons and dendrites and are tipped by …

During breast cancer metastasis cells emigrate from the primary tumor to the bloodstream,
and this carries them to distant sites where they infiltrate and sometimes form metastases …

The molecular and cellular mechanisms that allow adult-stage neurons to regenerate
following damage are poorly understood. Recently, axons of motoneurons and …

One of the challenges to understanding nervous system development has been to establish
how a fairly limited number of axon guidance cues can set up the patterning of very complex …