The physiological stress response is responsible for the maintenance of homeostasis in the
presence of real or perceived challenges. In this function, the brain activates adaptive …

The activation of cAMP-response element binding protein (CREB)-dependent gene
expression seems a crucial step in the molecular cascade that mediates the formation of …

The CRH receptor (CRH-R) is a member of the secretin family of G protein-coupled
receptors. Wide expression of CRH-Rs in the central nervous system and periphery ensures …

Stress induces the release of the peptide corticotropin‐releasing factor (CRF) into the ventral
tegmental area (VTA), and also increases dopamine levels in brain regions receiving dense …

Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

Learning and memory processes carried out within the hippocampus are influenced by
stress in a complex manner, and the mechanisms by which stress modulates the physiology …

Aggregation of the amyloid-β (Aβ) peptide in the extracellular space of the brain is critical in
the pathogenesis of Alzheimer's disease. Aβ is produced by neurons and released into the …

In the present experiments, we characterized the action of human/rat corticotropin-releasing
factor (h/rCRF) and acute stress (1 hr of immobilization) on hippocampus-dependent …

To investigate the role of CREB-mediated gene expression on the excitability of CA1
pyramidal neurons, we obtained intracellular recordings from pyramidal neurons of …

In mammals, the circadian oscillators that drive daily behavioral and endocrine rhythms are
located in the hypothalamic suprachiasmatic nucleus (SCN). While the SCN is anatomically …