The chirality of small metabolic molecules is important in controlling physiological processes
and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules …

Parkinson's disease is a progressive neurodegenerative disorder resulting from the
degeneration of pigmented dopaminergic neurons in the substantia nigra pars compacta. It …

Free d-amino acids (d-AAs) are emerging as a novel and important class of signaling
molecules in many organs, including the brain and endocrine systems. There has been …

DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different
chronic diseases including neurodegeneration, cancer and diabetes. Several of the …

Schizophrenia is a disorder of synaptic plasticity and aberrant connectivity in which a major
dysfunction in glutamate synapse has been suggested. However, a multi-level approach …

D-amino acids have been known to exist in the human brain for nearly 40 years, and they
continue to be a field of active study to today. This review article aims to give a concise …

L-serine generated in astrocytes plays a pivotal role in modulating essential neurometabolic
processes, while its enantiomer, D-serine, specifically regulates NMDA receptor (NMDAR) …

The D-aspartate oxidase (DDO) gene encodes the enzyme responsible for the catabolism of
D-aspartate, an atypical amino acid enriched in the mammalian brain and acting as an …

Loss of dopaminergic midbrain neurons perturbs l-serine and d-serine homeostasis in the
post-mortem caudate putamen (CPu) of Parkinson's disease (PD) patients. However, it is …

Imbalances of iron and dopamine metabolism along with mitochondrial dysfunction have
been linked to the pathogenesis of Parkinson's disease (PD). We have previously suggested …