The corneal epithelium serves to protect the underlying cornea from the external
environment and is essential for corneal transparency and optimal visual function …

The cornea comprises a pool of self-regenerating epithelial cells that are crucial to
preserving clarity and visibility. Limbal epithelial stem cells (LESCs), which live in a …

Whilst demonstrated extensively in vitro, the control of cell behaviour via modulation of
substrate compliance in live tissues has not been accomplished to date. Here we propose …

The functional heterogeneity of resident stem cells that support adult organs is incompletely
understood. Here, we directly visualize the corneal limbus in the eyes of live mice and …

Interactions between stem cells and their microenvironment are critical for regulation and
maintenance of stem cell function. To elucidate the molecular interactions within the human …

The cornea is a highly specialized organ that relies on its mechanical stiffness to maintain its
aspheric geometry and refractive power, and corneal diseases such as keratoconus have …

Recent studies have established that the phenotype of epithelial stem cells residing in the
corneal periphery (the limbus) depends on this niche's distinct biomechanical properties …

The transplantation of ex vivo expanded limbal epithelial progenitor cells (LEPCs) on
amniotic membrane or fibrin gel is an established therapeutic strategy to regenerate the …

Keeping the integrity and transparency of the cornea is the most important issue to ensure
normal vision. There are more than 10 million patients going blind due to the cornea …

The cornea is an ideal testing field for cell therapies. Its highly ordered structure, where
specific cell populations are sequestered in different layers, together with its accessibility …