The Golgi apparatus plays a central role in normal cell physiology by promoting cell survival,
facilitating proliferation, and enabling cell-cell communication and migration. These roles …

Cancer cells depend on altered metabolism and nutrient uptake to generate and keep the
malignant phenotype. The hexosamine biosynthetic pathway is a branch of glucose …

De novo uridine-diphosphate-N-acetylglucosamine (UDP-GlcNAc) biosynthesis requires
glucose, glutamine, acetyl-CoA and uridine, however GlcNAc salvaged from glycoconjugate …

There are five major classes of glycan including N-and O-glycans, glycosaminoglycans,
glycosphingolipids, and glycophosphatidylinositol anchors, all expressed at the molecular …

Aberrant N-glycan Golgi remodeling and metabolism are associated with epithelial–
mesenchymal transition (EMT) and metastasis in patients with breast cancer. Despite this …

Essential biological systems employ self-correcting mechanisms to maintain cellular
homeostasis. Mammalian cell function is dynamically regulated by the interaction of cell …

Here we describe isolation and characterization of macrophage-tumor cell fusions (MTFs)
from the blood of pancreatic ductal adenocarcinoma (PDAC) patients. The MTFs were …

Abstract The lectin, galectin-3 (Gal3), has been implicated in a variety of inflammatory and
oncogenic processes, including tumor growth, invasion, and metastasis. The interactions of …

Docetaxel (DTX) is a mainstay in the treatment of metastatic prostate cancer. Failure of DTX
therapy is often associated with multidrug resistance caused by overexpression of efflux …

Osteosarcoma (OS) is a high-grade malignant disease that is a prevalent primary malignant
sarcoma of the bone. The purpose of this investigation was to therefore elucidate the …