Emerging mechanistic understanding of cilia function in cellular signalling
Primary cilia are solitary, immotile sensory organelles present on most cells in the body that
participate broadly in human health, physiology and disease. Cilia generate a unique …
participate broadly in human health, physiology and disease. Cilia generate a unique …
Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca2+ signaling
A Balistrieri, A Makino, JXJ Yuan - Physiological reviews, 2023 - journals.physiology.org
The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …
GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation
G protein-coupled receptors (GPCRs) activate G proteins and undergo a complex regulation
by interaction with GPCR kinases (GRKs) and the formation of receptor–arrestin complexes …
by interaction with GPCR kinases (GRKs) and the formation of receptor–arrestin complexes …
Higher-order transient membrane protein structures
This study shows that five membrane proteins—three GPCRs, an ion channel, and an
enzyme—form self-clusters under natural expression levels in a cardiac-derived cell line …
enzyme—form self-clusters under natural expression levels in a cardiac-derived cell line …
Plasma membrane preassociation drives β-arrestin coupling to receptors and activation
Summary β-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and
desensitization. Despite recent structural advances, the mechanisms that govern receptor-β …
desensitization. Despite recent structural advances, the mechanisms that govern receptor-β …
Predicting biomolecular binding kinetics: A review
Biomolecular binding kinetics including the association (k on) and dissociation (k off) rates
are critical parameters for therapeutic design of small-molecule drugs, peptides, and …
are critical parameters for therapeutic design of small-molecule drugs, peptides, and …
Non-canonical interplay between glutamatergic NMDA and dopamine receptors shapes synaptogenesis
N Bénac, G Ezequiel Saraceno, C Butler… - Nature …, 2024 - nature.com
Direct interactions between receptors at the neuronal surface have long been proposed to
tune signaling cascades and neuronal communication in health and disease. Yet, the lack of …
tune signaling cascades and neuronal communication in health and disease. Yet, the lack of …
Opportunities and challenges in drug discovery targeting the orphan receptor GPR12
Abstract G-protein-coupled receptor 12 (GPR12) is a brain-specific expression orphan G-
protein-coupled receptor (oGPCR) that regulates various physiological processes. It is an …
protein-coupled receptor (oGPCR) that regulates various physiological processes. It is an …
[HTML][HTML] Transient, nano-scale, liquid-like molecular assemblies coming of age
A Kusumi, TA Tsunoyama, KGN Suzuki… - Current Opinion in Cell …, 2024 - Elsevier
This review examines the dynamic mechanisms underlying cellular signaling,
communication, and adhesion via transient, nano-scale, liquid-like molecular assemblies on …
communication, and adhesion via transient, nano-scale, liquid-like molecular assemblies on …
Regulation of mTOR signaling: Emerging role of cyclic nucleotide-dependent protein kinases and implications for cardiometabolic disease
The mechanistic target of rapamycin (mTOR) kinase is a central regulator of cell growth and
metabolism. It is the catalytic subunit of two distinct large protein complexes, mTOR complex …
metabolism. It is the catalytic subunit of two distinct large protein complexes, mTOR complex …