Key determinants of success in fecal microbiota transplantation: From microbiome to clinic

S Porcari, N Benech, M Valles-Colomer, N Segata… - Cell host & …, 2023 - cell.com
Fecal microbiota transplantation (FMT) has achieved satisfactory results in preventing the
recurrence of Clostridioides difficile infection, but these positive outcomes have only been …

SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection

P Feuerstadt, TJ Louie, B Lashner… - … England Journal of …, 2022 - Mass Medical Soc
Background Current therapies for recurrent Clostridioides difficile infection do not address
the disrupted microbiome, which supports C. difficile spore germination into toxin-producing …

New targets in inflammatory bowel disease therapy: 2021

NA Cohen, DT Rubin - Current opinion in gastroenterology, 2021 - journals.lww.com
New targets in inflammatory bowel disease therapy: 2021 : Current Opinion in
Gastroenterology New targets in inflammatory bowel disease therapy: 2021 : Current …

[HTML][HTML] Colonization of the live biotherapeutic product VE303 and modulation of the microbiota and metabolites in healthy volunteers

M Dsouza, R Menon, E Crossette, SK Bhattarai… - Cell Host & Microbe, 2022 - cell.com
Manipulation of the gut microbiota via fecal microbiota transplantation (FMT) has shown
clinical promise in diseases such as recurrent Clostridioides difficile infection (rCDI) …

Safety and efficacy of fecal microbiota transplantation for treatment of systemic lupus erythematosus: An EXPLORER trial

C Huang, P Yi, M Zhu, W Zhou, B Zhang, X Yi… - Journal of …, 2022 - Elsevier
Gut microbiota dysbiosis is involved in the development of systemic lupus erythematosus
(SLE). The safety and efficacy of fecal microbiota transplantation (FMT) for the treatment of …

Huangqin decoction ameliorates DSS-induced ulcerative colitis: Role of gut microbiota and amino acid metabolism, mTOR pathway and intestinal epithelial barrier

M Li, M Li, J Lei, Y Wu, Z Li, L Chen, C Zhou, J Su… - Phytomedicine, 2022 - Elsevier
Background The clinical treatment of ulcerative colitis (UC) is limited. A traditional Chinese
medicinal formula, Huangqin decoction (HQD), is chronicled in Shang Han Lun and is …

Combination therapy with indigo and indirubin for ulcerative colitis via reinforcing intestinal barrier function

J Xie, S Tian, J Liu, S Huang, M Yang… - Oxidative Medicine …, 2023 - Wiley Online Library
Indigo and indirubin, the active molecules of traditional Chinese medicine indigo naturalis,
exert therapeutic activity for ulcerative colitis (UC). Indigo and indirubin are isomers and …

Discovery and delivery strategies for engineered live biotherapeutic products

MK Heavey, D Durmusoglu, N Crook… - Trends in …, 2022 - cell.com
Genetically engineered microbes that secrete therapeutics, sense and respond to external
environments, and/or target specific sites in the gut fall under an emergent class of …

An update on fecal microbiota transplantation for the treatment of gastrointestinal diseases

KMJ Waller, RW Leong… - … of gastroenterology and …, 2022 - Wiley Online Library
Our understanding of the microbiome and its implications for human health and disease
continues to develop. Fecal microbiota transplantation (FMT) is now an established …

Translating microbiome research from and to the clinic

ZJ Zhang, CJ Lehmann, CG Cole… - Annual Review of …, 2022 - annualreviews.org
Extensive research has elucidated the influence of the gut microbiota on human health and
disease susceptibility and resistance. We review recent clinical and laboratory-based …