An evolutionary perspective on field cancerization
Tumorigenesis begins long before the growth of a clinically detectable lesion and, indeed,
even before any of the usual morphological correlates of pre-malignancy are recognizable …
even before any of the usual morphological correlates of pre-malignancy are recognizable …
Identification of genetic susceptibility loci for colorectal tumors in a genome-wide meta-analysis
BACKGROUND & AIMS: Heritable factors contribute to the development of colorectal
cancer. Identifying the genetic loci associated with colorectal tumor formation could …
cancer. Identifying the genetic loci associated with colorectal tumor formation could …
Discovery of common and rare genetic risk variants for colorectal cancer
To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …
Determining risk of colorectal cancer and starting age of screening based on lifestyle, environmental, and genetic factors
J Jeon, M Du, RE Schoen, M Hoffmeister, PA Newcomb… - Gastroenterology, 2018 - Elsevier
Background & Aims Guidelines for initiating colorectal cancer (CRC) screening are based
on family history but do not consider lifestyle, environmental, or genetic risk factors. We …
on family history but do not consider lifestyle, environmental, or genetic risk factors. We …
Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci
Multiple regulatory elements distant from their targets on the linear genome can influence
the expression of a single gene through chromatin looping. Chromosome conformation …
the expression of a single gene through chromatin looping. Chromosome conformation …
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk
Known genetic loci explain only a small proportion of the familial relative risk of colorectal
cancer (CRC). We conducted a genome-wide association study of CRC in East Asians with …
cancer (CRC). We conducted a genome-wide association study of CRC in East Asians with …
Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1
Hereditary mixed polyposis syndrome (HMPS) is characterized by apparent autosomal
dominant inheritance of multiple types of colorectal polyp, with colorectal carcinoma …
dominant inheritance of multiple types of colorectal polyp, with colorectal carcinoma …
Genetic architecture of colorectal cancer
U Peters, S Bien, N Zubair - Gut, 2015 - gut.bmj.com
Colorectal cancer (CRC) is a complex disease that develops as a consequence of both
genetic and environmental risk factors. A small proportion (3–5%) of cases arise from …
genetic and environmental risk factors. A small proportion (3–5%) of cases arise from …
Association analyses identify 31 new risk loci for colorectal cancer susceptibility
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a
strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases …
strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases …
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk
MG Dunlop, SE Dobbins, SM Farrington, AM Jones… - Nature …, 2012 - nature.com
We performed a meta-analysis of five genome-wide association studies to identify common
variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 …
variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 …