β-Cell replacement by in situ reprogramming of non-β-cells is a promising diabetes therapy.
Following the observation that near-total β-cell ablation in adult mice triggers the …

Cell-identity switches, in which terminally differentiated cells are converted into different cell
types when stressed, represent a widespread regenerative strategy in animals, yet they are …

Regeneration is a heroic biological process that restores tissue architecture and function in
the face of day-to-day cell loss or the aftershock of injury. Capacities and mechanisms for …

The cellular identity of pancreatic polypeptide (Ppy)-expressing γ-cells, one of the rarest
pancreatic islet cell-type, remains elusive. Within islets, glucagon and somatostatin …

In contrast to mice, zebrafish have an exceptional yet elusive ability to replenish lost β cells
in adulthood. Understanding this framework would provide mechanistic insights for β cell …

The primary cilium is an organelle present in most adult mammalian cells that is considered
as an antenna for sensing the local microenvironment. Here, we use intact mouse …

The pancreatic islet is a dense cellular network comprised of several cell types with
endocrine function vital in the control of glucose homeostasis, metabolism, and feeding …

Regeneration, the ability to replace injured tissues and organs, is a phenomenon commonly
associated with lower vertebrates but is also observed in mammals, in specific tissues. In …

Restoring damaged β-cells in diabetic patients by harnessing the plasticity of other
pancreatic cells raises the questions of the efficiency of the process and of the functionality …

Compromised β-cell identity is emerging as an important contributor to β-cell failure in
diabetes; however, the precise mechanism independent of hyperglycemia is under …