Periodontal diseases are initiated by bacterial species living in polymicrobial biofilms at or
below the gingival margin and progress largely as a result of the inflammation elicited by …

Bordetella respiratory infections are common in people (B. pertussis) and in animals (B.
bronchiseptica). During the last two decades, much has been learned about the virulence …

Whooping cough caused by Bordetella pertussis is a re-emerging infectious disease despite
the introduction of safer acellular pertussis vaccines (Pa). One explanation for this is that Pa …

Abstract T regulatory Type 1 (Tr1) cells are adaptive T regulatory cells characterized by the
ability to secrete high levels of IL-10 and minimal amounts of IL-4 and IL-17. Recently …

Bordetella pertussis causes whooping cough, a severe respiratory tract infection in infants
and children, and also infects adults. Studies in murine models have shown that innate …

Antigen-specific T helper type 1 (Th1) cells mediate protective immunity against a range of
infectious diseases, including that caused by Bordetella pertussis. Distinct T cell subtypes …

Objective To examine in a randomised trial whether a 25% difference in mortality exists
between 4.5 months and 3 years of age for children given two standard doses of Edmonston …

Many of the deadliest bacterial diseases that plague humanity in the modern age are
caused by bacterial biofilms that produce chronic infections. However, most of our …

In the mid-1990s, whole-cell pertussis (wP) vaccines were associated with local and
systemic adverse events that prompted their replacement with acellular pertussis (aP) …

Protective immunity wanes rapidly after immunization of children with acellular pertussis
(aP) vaccines and these vaccines do not prevent nasal colonization or transmission of …