Mechanical properties of materials for stem cell differentiation

SB Han, JK Kim, G Lee, DH Kim - Advanced Biosystems, 2020 - Wiley Online Library
Recent findings about cell fate change induced by physical stimuli have expedited the
discovery of underlying regulatory mechanisms that determine stem cell differentiation …

Mechanobiological strategies to enhance stem cell functionality for regenerative medicine and tissue engineering

M Shafiq, O Ali, SB Han, DH Kim - Frontiers in Cell and …, 2021 - frontiersin.org
Stem cells have been extensively used in regenerative medicine and tissue engineering;
however, they often lose their functionality because of the inflammatory microenvironment …

Lab-on-a-chip platforms as tools for drug screening in neuropathologies associated with blood–brain barrier alterations

CE Staicu, F Jipa, E Axente, M Radu, BM Radu, F Sima - Biomolecules, 2021 - mdpi.com
Lab-on-a-chip (LOC) and organ-on-a-chip (OOC) devices are highly versatile platforms that
enable miniaturization and advanced controlled laboratory functions (ie, microfluidics …

Enhancement of intracellular calcium ion mobilization by moderately but not highly positive material surface charges

M Gruening, S Neuber, P Nestler, J Lehnfeld… - … in bioengineering and …, 2020 - frontiersin.org
Electrostatic forces at the cell interface affect the nature of cell adhesion and function; but
there is still limited knowledge about the impact of positive or negative surface charges on …

Design and manufacture of 3D cell culture plate for mass production of cell-spheroids

D Lee, S Pathak, JH Jeong - Scientific Reports, 2019 - nature.com
A 3D cell culture is preferred to 2D cell culture since it allows cells to grow in all directions in
vitro, similar to how they would in vivo. 3D cell culture plates currently used in tissue …

Neurosphere development from hippocampal and cortical embryonic mixed primary neuron culture: a potential platform for screening neurochemical modulator

J Khan, G Das, V Gupta, S Mohapatra… - ACS chemical …, 2018 - ACS Publications
Reconstitution of a complex biological structure or system following a simple and facile
strategy using minimum physiochemical cues is challenging for an in-depth understanding …

Fabrication approaches for high-throughput and biomimetic disease modeling

ML Grubb, SR Caliari - Acta biomaterialia, 2021 - Elsevier
There is often a tradeoff between in vitro disease modeling platforms that capture
pathophysiologic complexity and those that are amenable to high-throughput fabrication and …

Fabrication of Convex PDMS–Parylene Microstructures for Conformal Contact of Planar Micro-Electrode Array

WR Lee, C Im, HY Park, JM Seo, JM Kim - Polymers, 2019 - mdpi.com
Polymer-based micro-electrode arrays (MEAs) are gaining attention as an essential
technology to understand brain connectivity and function in the field of neuroscience …

Engineered Biomimetic platforms to analyse molecular and cellular role of Heparan Sulfate on BMP2 bioactivity

J Sefkow-Werner - 2021 - theses.hal.science
The extra cellular matrix (ECM) provides mechanical structure to embedded cells and gives
biochemical cues to regulate homeostasis and differentiation. The structural molecule …

Effects of Metabolism on Mesenchymal Stem Cell-Derived Extracellular Vesicles

R Lee - 2020 - search.proquest.com
Mesenchymal stem cells (MSCs) are under investigation for a wide variety of therapeutic
applications. It has been determined that paracrine secretions are responsible for a …