Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …

Aldo-keto reductases (AKRs) are monomeric NAD (P)(H)-dependent oxidoreductases that
play pivotal roles in the biosynthesis and metabolism of steroids in humans. AKR1C …

Abstract Aldo-Keto-Reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase
(HSD)/prostaglandin (PG) F 2α synthase) is the only 17β-HSD that is not a short-chain …

Aldo-keto reductases (AKRs) are promiscuous NAD (P)(H) dependent oxidoreductases
implicated in the metabolic activation of polycyclic aromatic hydrocarbons (PAH). These …

During pregnancy, uterine quiescence is maintained by increased progesterone receptor
(PR) activity, but labor is facilitated by a series of events that impair PR function. Previously …

Polycyclic aromatic hydrocarbons (PAHs), dioxin-like compounds (DLCs) and structurally-
related environmental pollutants may contribute to the pathogenesis of various diseases and …

Aldo-keto reductase family 1 member C3 (AKR1C3) serves as a contributor to numerous
kinds of tumors, and its expression is elevated in patients with hepatocellular carcinoma …

Cell types with specialized functions fundamentally regulate animal behaviour, and yet the
genetic mechanisms that underlie the emergence of novel cell types and their …

Background Excessive estrogen exposure is an important pathogenic factor in uterine
endometrial cancer (UEC). Recent studies have reported the metabolic properties can …

Polycyclic aromatic hydrocarbons (PAH) are ubiquitous environmental pollutants. They are
procarcinogens requiring metabolic activation to elicit their deleterious effects. Aldo-keto …