Pancreatic β-cell electrical activity and insulin secretion: of mice and men
P Rorsman, FM Ashcroft - Physiological reviews, 2018 - journals.physiology.org
The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …
The triggering pathway to insulin secretion: Functional similarities and differences between the human and the mouse β cells and their translational relevance
In β cells, stimulation by metabolic, hormonal, neuronal, and pharmacological factors is
coupled to secretion of insulin through different intracellular signaling pathways. Our …
coupled to secretion of insulin through different intracellular signaling pathways. Our …
Genetic regulatory signatures underlying islet gene expression and type 2 diabetes
Genome-wide association studies (GWAS) have identified> 100 independent SNPs that
modulate the risk of type 2 diabetes (T2D) and related traits. However, the pathogenic …
modulate the risk of type 2 diabetes (T2D) and related traits. However, the pathogenic …
Role of TREK-1 in health and disease, focus on the central nervous system
A Djillani, J Mazella, C Heurteaux… - Frontiers in …, 2019 - frontiersin.org
TREK-1 is the most studied background K2P channel. Its main role is to control cell
excitability and maintain the membrane potential below the threshold of depolarization …
excitability and maintain the membrane potential below the threshold of depolarization …
[HTML][HTML] Beta-cell ion channels and their role in regulating insulin secretion
B Thompson, LS Satin - Comprehensive physiology, 2021 - ncbi.nlm.nih.gov
Beta cells of the pancreatic islet express many different types of ion channels. These
channels reside in the β-cell plasma membrane as well as subcellular organelles and their …
channels reside in the β-cell plasma membrane as well as subcellular organelles and their …
SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
Insulin secretion is initiated by activation of voltage-gated Ca2+ channels (VGCC) to trigger
Ca2+-mediated insulin vesicle fusion with the β-cell plasma membrane. The firing of VGCC …
Ca2+-mediated insulin vesicle fusion with the β-cell plasma membrane. The firing of VGCC …
RIPK3-mediated inflammation is a conserved β cell response to ER stress
B Yang, LA Maddison, KE Zaborska, C Dai, L Yin… - Science …, 2020 - science.org
Islet inflammation is an important etiopathology of type 2 diabetes; however, the underlying
mechanisms are not well defined. Using complementary experimental models, we …
mechanisms are not well defined. Using complementary experimental models, we …
Ion channels of the islets in type 2 diabetes
DA Jacobson, SL Shyng - Journal of molecular biology, 2020 - Elsevier
Ca 2+ is an essential signal for pancreatic β-cell function. Ca 2+ plays critical roles in
numerous β-cell pathways such as insulin secretion, transcription, metabolism, endoplasmic …
numerous β-cell pathways such as insulin secretion, transcription, metabolism, endoplasmic …
Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca2+-Regulated Genes
JS Stancill, JP Cartailler, HW Clayton, JT O'Connor… - Diabetes, 2017 - Am Diabetes Assoc
We used mice lacking Abcc8, a key component of the β-cell KATP-channel, to analyze the
effects of a sustained elevation in the intracellular Ca2+ concentration ([Ca2+] i) on β-cell …
effects of a sustained elevation in the intracellular Ca2+ concentration ([Ca2+] i) on β-cell …
Beta-cell hubs maintain Ca2+ oscillations in human and mouse islet simulations
Islet β-cells are responsible for secreting all circulating insulin in response to rising plasma
glucose concentrations. These cells are a phenotypically diverse population that express …
glucose concentrations. These cells are a phenotypically diverse population that express …