Herpes simplex virus-1 (HSV-1) infects the majority of the world's population. These
infections are often asymptomatic, but ocular HSV-1 infections cause multiple pathologies …

Viruses manipulate the function of dendritic cells (DCs) to enhance their entry, spread,
survival and transmission. This review summarises recently published work identifying how …

During a screen for ethylnitrosourea-induced mutations in mice affecting blood natural killer
(NK) cells, we identified a strain, designated Duane, in which NK cells were reduced in …

Herpes simplex virus type 1 (HSV-1) is capable of causing a latent infection in sensory
neurons that lasts for the lifetime of the host. The primary infection is resolved following the …

Immune responses against HSV-1 and HSV-2 are complex and involve a delicate interplay
between innate signaling pathways and adaptive immune responses. The innate response …

Keratitis is one of the most prevalent ocular diseases manifested by partial or total loss of
vision. Amongst infectious (viz., microbes including bacteria, fungi, amebae, and viruses) …

Natural Killer (NK) cells play a critical role in host defense against viral infections. The
mechanisms of recognition and killing of virus-infected cells mediated by NK cells are still …

NK cells infiltrate human herpetic lesions, but their role has been underexplored. HSV can
stimulate innate immune responses via surface TLR2, which is expressed on monocyte …

Dendritic cells (DCs) regulate both innate and adaptive immune responses. In this article,
we exploit the unique avascularity of the cornea to examine a role for local or very early …

Rationale: Lung natural killer cells (NKs) kill a greater percentage of autologous lung
parenchymal cells in chronic obstructive pulmonary disease (COPD) than in nonobstructed …