The MYC gene which consists of 3 paralogs, C-MYC, N-MYC and L-MYC, is one of the most
frequently deregulated driver genes in human cancer. Because of its high prevalence of …

Epigenetics has been defined as 'the structural adaptation of chromosomal regions so as to
register, signal or perpetuate altered activity states.'Currently, several classes of anticancer …

Lysine acetylation is a key mechanism that regulates chromatin structure; aberrant
acetylation levels have been linked to the development of several diseases. Acetyl-lysine …

Genetic alterations affecting RAS proteins are commonly found in human cancers. Roughly
a fourth of melanoma patients carry activating NRAS mutations, rendering this malignancy …

BRD4, the most extensively studied member of the BET family, is an epigenetic regulator
that localizes to DNA via binding to acetylated histones and controls the expression of …

Purpose: Bromodomain and extraterminal (BET) proteins play important roles in
transcriptional regulation relevant to cancer pathogenesis, and therapeutic …

Unsustained enzyme inhibition is a barrier to targeted therapy for cancer. Here, resistance to
a class I PI3K inhibitor in a model of metastatic breast cancer driven by PI3K and MYC was …

Small-molecule BET bromodomain inhibitors (BETis) are actively being pursued in clinical
trials for the treatment of a variety of cancers, but the mechanisms of resistance to BETis …

Glioblastoma (GBM) is the most common primary brain tumor in adults, and the most lethal
form of glioma, characterized by variable histopathology, aggressiveness and poor clinical …

Transcription factors and chromatin-remodeling complexes are key determinants of
embryonic stem cell (ESC) identity. Here, we demonstrate that BRD4, a member of the …