Most mammalian cells contain vanadium at a concentration of about 20 nM, the bulk of
which is probably in the reduced vanadyl (+ 4) form. Although this trace element is essential …

Dysfunction of specific hypothalamic neurons is regarded as an important mechanism
predisposing to the development of obesity. Recent studies have revealed that the …

The regulation of tyrosine phosphorylation and associated signalling through antigen,
growth-factor and cytokine receptors is mediated by the reciprocal activities of protein …

Evidence demonstrates that exogenous nitric oxide (NO) and the NO produced by inducible
nitric oxide synthase (iNOS) can induce insulin resistance in muscle. Here, we investigated …

A insulina é um hormônio anabólico com efeitos metabólicos potentes. Os eventos que
ocorrem após a ligação da insulina são específicos e estritamente regulados. Definir as …

Non-alcoholic fatty liver disease, induced by nutritional factors, is one of the leading causes
of hepatic dysfunction in the modern world. The activation of proinflammatory signaling in …

DNA methylation acts at the interface of genetic and environmental factors relevant for
autism spectrum disorder (ASD). Placenta, normally discarded at birth, is a potentially rich …

The tyrosine kinase JAK2 is a key signaling protein for at least 20 receptors in the cytokine/
hematopoietin receptor superfamily and is a component of signaling by insulin receptor and …

Objective: To investigate whether insulin and leptin share common intracellular signal
transduction pathways and to determine whether these hormonal signaling systems …

Background Endurance training increases insulin-stimulated muscle glucose transport and
leads to improved metabolic control in diabetic patients. Objective To analyze the effects of …