Recent advances in microfluidic platforms applied in cancer metastasis: Circulating tumor cells'(CTCs) isolation and tumor‐on‐a‐chip

Z Lin, G Luo, W Du, T Kong, C Liu, Z Liu - Small, 2020 - Wiley Online Library
Cancer remains the leading cause of death worldwide despite the enormous efforts that are
made in the development of cancer biology and anticancer therapeutic treatment …

The prognostic role of circulating tumor cells (CTCs) in lung cancer

J Kapeleris, A Kulasinghe, ME Warkiani, I Vela… - Frontiers in …, 2018 - frontiersin.org
Lung cancer affects over 1. 8 million people worldwide and is the leading cause of cancer
related mortality globally. Currently, diagnosis of lung cancer involves a combination of …

[HTML][HTML] A refined culture system for human induced pluripotent stem cell-derived intestinal epithelial organoids

Y Takahashi, S Sato, Y Kurashima, T Yamamoto… - Stem cell reports, 2018 - cell.com
Gut epithelial organoids are routinely used to investigate intestinal biology; however, current
culture methods are not amenable to genetic manipulation, and it is difficult to generate …

Autologous cell lines from circulating colon cancer cells captured from sequential liquid biopsies as model to study therapy-driven tumor changes

A Soler, L Cayrefourcq, T Mazard, A Babayan… - Scientific reports, 2018 - nature.com
Circulating tumor cells (CTCs) are important clinical indicators for prognosis and treatment
efficacy. However, CTC investigation is hampered by their low number, making the …

Circulating tumor cells in cancer diagnostics and prognostics by single-molecule and single-cell characterization

T Chowdhury, B Cressiot, C Parisi, G Smolyakov… - ACS …, 2023 - ACS Publications
Circulating tumor cells (CTCs) represent an interesting source of biomarkers for diagnosis,
prognosis, and the prediction of cancer recurrence, yet while they are extensively studied in …

Enrichment of circulating head and neck tumour cells using spiral microfluidic technology

A Kulasinghe, THP Tran, T Blick, K O'Byrne… - Scientific reports, 2017 - nature.com
Whilst locoregional control of head and neck cancers (HNCs) has improved over the last
four decades, long-term survival has remained largely unchanged. A possible reason for this …

Ex vivo expanded circulating tumor cells for clinical anti-cancer drug prediction in patients with head and neck cancer

KC Lin, LL Ting, CL Chang, LS Lu, HL Lee, FC Hsu… - Cancers, 2021 - mdpi.com
Simple Summary The conventional methods that seek to predict clinical treatment response
are based on the number of circulating tumor cells (CTCs) present in liquid biopsies or …

Single-cell analysis of circulating tumour cells: enabling technologies and clinical applications

P Radfar, HA Es, R Salomon, A Kulasinghe… - Trends in …, 2022 - cell.com
Multimodal analysis of circulating tumour cells (CTCs) has the potential to provide
remarkable insight for cancer development and metastasis. CTCs and CTC clusters …

The use of microfluidic technology for cancer applications and liquid biopsy

A Kulasinghe, H Wu, C Punyadeera, ME Warkiani - Micromachines, 2018 - mdpi.com
There is growing awareness for the need of early diagnostic tools to aid in point-of-care
testing in cancer. Tumor biopsy remains the conventional means in which to sample a tumor …

Preclinical models to study patient-derived circulating tumor cells and metastasis

KN Suvilesh, Y Manjunath, K Pantel, JT Kaifi - Trends in Cancer, 2023 - cell.com
Circulating tumor cells (CTCs) that are detached from the tumor can be precursors of
metastasis. The majority of studies focus on enumeration of CTCs from patient blood to …